Immunological aspects of the efficiency of protectotype vaccination strategy against chicken infectious bronchitis

BMC Veterinary Research

Research Article

Bartlomiej Tykalowski¹  Marcin Smialek¹  Tomasz Stenzel¹  Andrzej Koncicki¹  Daria Dziewulska¹ 

[1] Departemnt of Poultry Diseases, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10-719, Olsztyn, Poland;

关键词: Chicken;    IB;    Protectotype vaccination strategy;    CMI;    Humoral immunity;   

DOI  :  10.1186/s12917-017-0963-1

 received in 2016-10-07, accepted in 2017-01-31,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundOne of the most commonly applied protectotype vaccination protocol against infectious bronchitis (IB) in broiler chickens in the EU is simultaneous or alternate use of Ma5 and 4/91 vaccine strains. After IB vaccination and infection, systemic and upper respiratory tract (URT), humoral and cell-mediated immunity (CMI), are stimulated. The level of this stimulation correlates with the level of protection against IB.ResultsWe’ve investigated the development of URT and systemic, cell-mediated and humoral immunity in commercial broiler chickens vaccinated with Ma5 and/or 4/91 strains at hatch day. We’ve demonstrated that the group vaccinated with Ma5 and 4/91 strain simultaneously developed the most desirable immunity which reflects the level of CD8+ T cells stimulation in spleen and Harderian gland, as well as the level of IgA and IgY in URT washings and serum and their cross-reactivity with 7 IBV strains.ConclusionsAlthough we did not demonstrate directly why Ma5 + 4/91 protocol is so efficient it seems that it combines the benefits of monovalent vaccination with either Ma5 or 4/91 and while Ma5 seems to stimulate CMI more efficiently, the 4/91 strain generates a wider spectrum of immune system cross-reactivity and higher URT IgA production.

【 授权许可】

CC BY   
© The Author(s). 2017