The ratio of skeletal muscle mass to visceral fat area is a main determinant linking circulating irisin to metabolic phenotype

Cardiovascular Diabetology

Original Investigation

Byung-Soo Youn¹  Won Seon Jeon²  Cheol-Young Park²  You-Cheol Hwang³ 

[1] Biomedical Research Center, Ulsan University Hospital, University of Ulsan College of Medicine, 877 Bangeojinsunwhando-ro, Dong-gu, 44033, Ulsan, Republic of Korea;Department of Internal Medicine, Division of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Pyung-Dong, Jongro-Gu, 110-746, Seoul, Republic of Korea;Department of Medicine, Division of Endocrinology and Metabolism, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Republic of Korea;

关键词: Irisin;    Skeletal muscle;    Visceral fat;    Glucose tolerance;    Insulin sensitivity;   

DOI  :  10.1186/s12933-015-0319-8

 received in 2015-09-08, accepted in 2015-12-23,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe aims of this study were to investigate whether circulating irisin is associated with favorable metabolic parameters and how the association differs according to body composition in humans.MethodsA total of 424 subjects (233 men and 191 women), aged 23–73 years (mean age 47.1 years), were enrolled from the Seoul Metro City Diabetes Prevention Program. Body composition was determined using an impedance body composition analyzer, and serum irisin level was measured using a commercial kit.ResultsSerum irisin was correlated with favorable metabolic parameters including less obese, lower blood pressure and glucose levels and healthy lipid parameters. The skeletal muscle mass to visceral fat area ratio (SVR) was positively correlated with the serum irisin concentration (r = 0.10, P = 0.04). When the study subjects were divided into tertiles according to their SVR, serum irisin was correlated with favorable metabolic phenotypes in those subjects in the upper tertile. However, there were no such correlations in the lower tertile. In addition, serum irisin was inversely related to pre-diabetes/type 2 diabetes (T2D) independent of other risk factor for T2D and insulin resistance [OR (95 % CI); 0.66 (0.49–0.90), P = 0.009].ConclusionsThe compositions of skeletal muscle and visceral fat play key roles in the association between circulating irisin and a patient’s metabolic phenotype.

【 授权许可】

CC BY   
© Hwang et al. 2016