Swimming exercise increases serum irisin level and reduces body fat mass in high-fat-diet fed Wistar rats

Lipids in Health and Disease

Research

Ming Xu¹  Feng Li²  Ling Wang²  Jing-Ting Yun²  Yin-Bo Feng²  Yun Lu²  Hongwei Li²  Zhen-Hai Shen³  Shi-Wei Shen⁴  Cheng-Jian Yang⁴  Hua-Jin Qi⁴ 

[1] Jiangsu Institute of Parasitic Diseases, 214064, Wuxi City, Jiangsu Province, China;Jiangsu Provincial Taihu Lake Rehabilitation Hospital of Jiangsu Provincial People’s Hospital Group, 214086, Wuxi City, Jiangsu Province, China;Jiangsu Provincial Taihu Lake Rehabilitation Hospital of Jiangsu Provincial People’s Hospital Group, 214086, Wuxi City, Jiangsu Province, China;Jiangsu Provincial Taihu Cadre’s Sanatorium of Jiangsu Provincial People’s Hospital Group, 214086, Wuxi City, Jiangsu Province, China;Wuxi No. 2 People’s Hospital Affiliated to Nanjing Medical University, 214002, Wuxi City, Jiangsu Province, China;

关键词: Swimming exercise;    Irisin;    Dual-energy X-ray absorptiometry (DXA);    Visceral fat;   

DOI  :  10.1186/s12944-016-0263-y

 received in 2015-12-17, accepted in 2016-05-05,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundIt has been shown that irisin levels are reduced in skeletal muscle and plasma of obese rats; however, the effect of exercise training on irisin level remains controversial. We aim to evaluate the association of swimming exercise with serum irisin level and other obesity-associated parameters.MethodsForty healthy male Wistar rats were randomly assigned to 4 groups: a normal diet and sedentary group (ND group), normal diet and exercise group (NDE group), high-fat diet and sedentary group (HFD group), and high-fat diet and exercise group (HFDE group. After 8 consecutive weeks of swimming exercise, fat mass and serum irisin level was determined.ResultsHigher serum irisin levels were detected in the HFDE group (1.15 ± 0.28 μg/L) and NDE group (1.76 ± 0.17 μg/L) than in the HFD group (0.84 ± 0.23 μg/L) or the ND group (1.24 ± 0.29 μg/L), respectively (HFDE group vs. HFD group, P < 0.05; NDE group vs. ND group, P < 0.01). Pearson’s correlation analysis showed that serum irisin level negatively correlated with TG level (r = −0.771, P < 0.05), percentage fat mass (r = −0.68, P < 0.05), fat mass (r = −0.576, P < 0.05), visceral fat mass (r = −0.439, P < 0.05) and TC level (r = −0.389, P < 0.05). The fat mass, visceral fat mass and percentage fat mass were lower in the HFDE group than the HFD group (all P values < 0.01).ConclusionSwimming exercise decreases body fat mass in high-fat-fed Wistar rats, which may be attributable to elevated irisin levels induced by swimming exercise.

【 授权许可】

CC BY   
© Lu et al. 2016