Uncoupling protein 2 gene polymorphisms are associated with obesity

Cardiovascular Diabetology

Original Investigation

Made R Saraswati¹  Pande Dwipayana¹  Ketut Suastika¹  Clarissa A Febinia²  Wibowo Arindrarto²  Sukma Oktavianthi²  Hidayat Trimarsanto²  Safarina G Malik²  Herawati Sudoyo² 

[1] Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine Udayana University, Jl. P.B. Sudirman and Sanglah Hospital, Jl. Kesehatan, Denpasar, Indonesia;Eijkman Institute for Molecular Biology, Jl. Diponegoro 69, 10430, Jakarta, Indonesia;

关键词: UCP2;    Ala55Val;    G(−866)A;    Obesity;    Serum lipids;    Type 2 diabetes mellitus;   

DOI  :  10.1186/1475-2840-11-41

 received in 2011-12-19, accepted in 2012-04-25,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundUncoupling protein 2 (UCP2) gene polymorphisms have been reported as genetic risk factors for obesity and type 2 diabetes mellitus (T2DM). We examined the association of commonly observed UCP2 G(−866)A (rs659366) and Ala55Val (C > T) (rs660339) single nucleotide polymorphisms (SNPs) with obesity, high fasting plasma glucose, and serum lipids in a Balinese population.MethodsA total of 603 participants (278 urban and 325 rural subjects) were recruited from Bali Island, Indonesia. Fasting plasma glucose (FPG), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) were measured. Obesity was determined based on WHO classifications for adult Asians. Participants were genotyped for G(−866)A and Ala55Val polymorphisms of the UCP2 gene.ResultsObesity prevalence was higher in urban subjects (51%) as compared to rural subjects (23%). The genotype, minor allele (MAF), and heterozygosity frequencies were similar between urban and rural subjects for both SNPs. All genotype frequencies were in Hardy-Weinberg equilibrium. A combined analysis of genotypes and environment revealed that the urban subjects carrying the A/A genotype of the G(−866)A SNP have higher BMI than the rural subjects with the same genotype. Since the two SNPs showed strong linkage disequilibrium (D’ = 0.946, r2 = 0.657), a haplotype analysis was performed. We found that the AT haplotype was associated with high BMI only when the urban environment was taken into account.ConclusionsWe have demonstrated the importance of environmental settings in studying the influence of the common UCP2 gene polymorphisms in the development of obesity in a Balinese population.

【 授权许可】

Unknown   
© Oktavianthi et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.