Association between UCP2 A55V polymorphism and risk of cardiovascular events in patients with multi-vessel coronary arterial disease

BMC Medical Genetics

Whady A Hueb¹  Alexandre C Pereira¹  José Eduardo Krieger¹  Noely E Ferreira¹  Luisa S Sugaya¹  Paulo CJL Santos¹  Luciana Gioli-Pereira¹ 

[1] Heart Institute (InCor), Sao Paulo University Medical School, Av. Dr. Enéas de Carvalho Aguiar, 44 Cerqueira César, São Paulo - SP, 05403-000, Brazil

关键词: Diabetes;    Coronary artery disease;    A55V polymorphism;    UCP2;   

Others  :  1177713
DOI  :  10.1186/1471-2350-14-40

 received in 2011-11-17, accepted in 2013-03-18,  发布年份 2013

【 摘 要 】

Background

UCP2 (uncoupling protein 2) plays an important role in cardiovascular diseases and recent studies have suggested that the A55V polymorphism can cause UCP2 dysfunction. The main aim was to investigate the association of A55V polymorphism with cardiovascular events in a group of 611 patients enrolled in the Medical, Angioplasty or Surgery Study II (MASS II), a randomized trial comparing treatments for patients with coronary artery disease and preserved left ventricular function.

Methods

The participants of the MASS II were genotyped for the A55V polymorphism using allele-specific PCR assay. Survival curves were calculated with the Kaplan–Meier method and evaluated with the log-rank statistic. The relationship between baseline variables and the composite end-point of cardiac death, acute myocardial infarction (AMI), refractory angina requiring revascularization and cerebrovascular accident were assessed using a Cox proportional hazards survival model.

Results

There were no significant differences for baseline variables according genotypes. After 2 years of follow-up, dysglycemic patients harboring the VV genotype had higher occurrence of AMI (p=0.026), Death+AMI (p=0.033), new revascularization intervention (p=0.009) and combined events (p=0.037) as compared with patients carrying other genotypes. This association was not evident in normoglycemic patients.

Conclusions

These findings support the hypothesis that A55V polymorphism is associated with UCP2 functional alterations that increase the risk of cardiovascular events in patients with previous coronary artery disease and dysglycemia.

【 授权许可】

   
2013 Gioli-Pereira et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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