Air pollution exposure estimation using dispersion modelling and continuous monitoring data in a prospective birth cohort study in the Netherlands

Environmental Health

Methodology

Albert Hofman¹  Vincent WV Jaddoe²  Edith H Van den Hooven³  Ernst W Meijer⁴  Peter YJ Zandveld⁴  Yvonne De Kluizenaar⁴  Sjoerd W Van Ratingen⁴  Henk ME Miedema⁴  Frank H Pierik⁴ 

[1] Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands;The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands;Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands;Department of Paediatrics, Erasmus Medical Center, Rotterdam, The Netherlands;The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands;Urban Environment and Safety, TNO, Utrecht, The Netherlands;Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands;Urban Environment and Safety, TNO, Utrecht, The Netherlands;

关键词: Air pollution;    Dispersion modelling;    Particulate matter;    Nitrogen dioxide;    Cohort study;    Pregnant women;    Prenatal development;    Child health;   

DOI  :  10.1186/1476-069X-11-9

 received in 2011-09-09, accepted in 2012-02-22,  发布年份 2012

来源: Springer

【 摘 要 】

Previous studies suggest that pregnant women and children are particularly vulnerable to the adverse effects of air pollution. A prospective cohort study in pregnant women and their children enables identification of the specific effects and critical periods. This paper describes the design of air pollution exposure assessment for participants of the Generation R Study, a population-based prospective cohort study from early pregnancy onwards in 9778 women in the Netherlands. Individual exposures to PM10 and NO2 levels at the home address were estimated for mothers and children, using a combination of advanced dispersion modelling and continuous monitoring data, taking into account the spatial and temporal variation in air pollution concentrations. Full residential history was considered. We observed substantial spatial and temporal variation in air pollution exposure levels. The Generation R Study provides unique possibilities to examine effects of short- and long-term air pollution exposure on various maternal and childhood outcomes and to identify potential critical windows of exposure.

【 授权许可】

Unknown   
© van den Hooven et al; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.