The association between air pollution and the severity at diagnosis and progression of systemic sclerosis-associated interstitial lung disease: results from the retrospective ScleroPol study

Respiratory Research

Research

Frédéric Caux¹  Robin Dhote²  Benjamin Chaigne³  Luc Mouthon³  Bertrand Dunogue³  Frédérique Aubourg⁴  Anaïs Roeser⁵  Hilario Nunes⁶  Yurdagül Uzunhan⁶  Lucile Sese⁶  Guillaume Chassagnon⁷  Marie Pierre Revel⁷  Pierre-Yves Brillet⁸  Salma Jebri⁸  Stéphane Tran Ba⁸  Isabella Annesi-Maesano⁹ 

[1]Department of Dermatology, Assistance Publique-Hôpitaux de Paris (APHP), Avicenne Hospital, Paris, France

[2]Department of Internal Medicine, Assistance Publique-Hôpitaux de Paris (APHP), Avicenne Hospital, Paris, France

[3]Department of Internal Medicine, Assistance Publique-Hôpitaux de Paris (APHP), Cochin Hospital, Paris, France

[4]Department of Physiology, Assistance Publique-Hôpitaux de Paris (APHP), Cochin Hospital, Paris, France

[5]Department of Pulmonology, Assistance Publique-Hôpitaux de Paris (APHP), Avicenne Hospital, Bobigny, France

[6]Department of Pulmonology, Assistance Publique-Hôpitaux de Paris (APHP), Avicenne Hospital, Bobigny, France

[7]INSERM UMR1272 Hypoxie et poumon, Paris 13 - Université Paris Nord, Bobigny, France

[8]Department of Radiology A, Assistance Publique-Hôpitaux de Paris (APHP), Cochin Hospital, Paris, France

[9]Department of Radiology, Assistance Publique-Hôpitaux de Paris (APHP), Avicenne Hospital, Bobigny, France

[10]INSERM, Department of Allergic and Respiratory Disease, Montpellier University Hospital, Institute Desbrest of Epidemiology and Public Health, University of Montpellier, Montpellier, France

关键词: Systemic sclerosis;    Scleroderma;    Interstitial lung disease;    Air pollution;    Ozone;    Particulate matter;    Nitrogen dioxide;    Severity;    Progression;    CHIMERE;   

DOI  :  10.1186/s12931-023-02463-w

 received in 2023-01-05, accepted in 2023-05-26,  发布年份 2023

来源: Springer

【 摘 要 】

ObjectiveTo investigate the association of air pollution exposure with the severity of interstitial lung disease (ILD) at diagnosis and ILD progression among patients with systemic sclerosis (SSc)-associated ILD.MethodsWe conducted a retrospective two-center study of patients with SSc-associated ILD diagnosed between 2006 and 2019. Exposure to the air pollutants particulate matter of up to 10 and 2.5 µm in diameter (PM10, PM2.5), nitrogen dioxide (NO2), and ozone (O3) was assessed at the geolocalization coordinates of the patients’ residential address. Logistic regression models were used to evaluate the association between air pollution and severity at diagnosis according to the Goh staging algorithm, and progression at 12 and 24 months.ResultsWe included 181 patients, 80% of whom were women; 44% had diffuse cutaneous scleroderma, and 56% had anti-topoisomerase I antibodies. ILD was extensive, according to the Goh staging algorithm, in 29% of patients. O3 exposure was associated with the presence of extensive ILD at diagnosis (adjusted OR: 1.12, 95% CI 1.05–1.21; p value = 0.002). At 12 and 24 months, progression was noted in 27/105 (26%) and 48/113 (43%) patients, respectively. O3 exposure was associated with progression at 24 months (adjusted OR: 1.10, 95% CI 1.02–1.19; p value = 0.02). We found no association between exposure to other air pollutants and severity at diagnosis and progression.ConclusionOur findings suggest that high levels of O3 exposure are associated with more severe SSc-associated ILD at diagnosis, and progression at 24 months.

【 授权许可】

CC BY   
© The Author(s) 2023

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