Upper gastrointestinal bleeding due to peptic ulcer disease is not associated with air pollution: a case-crossover study

BMC Gastroenterology

Research Article

Markey Johnson¹  Paul J. Villeneuve²  Karen Madsen³  Sander Veldhuyzen van Zanten³  Eddy Lang⁴  Hong Yang⁵  Subrata Ghosh⁵  Samuel Quan⁵  Robert Hilsden⁵  Divine Tanyingoh⁵  Gilaad G. Kaplan⁵  Kerri Novak⁵  David M. Stieb⁶ 

[1] Air Health Science Division, Health Canada, K1A 0K9, Ottawa, Ontario, Canada;Department of Health Sciences, Carleton University, Ottawa, K1S 5B6, Ottawa, Ontario, Canada;Department of Medicine, University of Alberta, T6G-2R7, Edmonton, Alberta, Canada;Departments of Emergency Medicine, University of Calgary, T2N-4N1, Calgary, Alberta, Canada;Departments of Medicine and Community Health Sciences, University of Calgary, 3280 Hospital Drive NW, Room 6D56, T2N-4N1, Calgary, AB, Canada;Population Studies Division, Health Canada, V6C 1A1, Vancouver, British Columbia, Canada;

关键词: Air pollution;    Peptic ulcer disease;    Upper gastrointestinal bleeding;    Particulate matter;    Nitrogen dioxide;   

DOI  :  10.1186/s12876-015-0363-6

 received in 2015-06-03, accepted in 2015-10-01,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundRecent studies have demonstrated an association between short-term elevations in air pollution and an increased risk of exacerbating gastrointestinal disease. The objective of the study was to evaluate if day-to-day increases in air pollution concentrations were positively associated with upper gastrointestinal bleeding (UGIB) secondary to peptic ulcer disease (PUD).MethodsA time-stratified case-crossover study design was used. Adults presenting to hospitals with their first UGIB secondary to PUD from 2004–2010 were identified using administrative databases from Calgary (n = 1374; discovery cohort) and Edmonton (n = 1159; replication cohort). Daily concentrations of ozone, nitrogen dioxide, sulfur dioxide, carbon monoxide, and particulate matter (PM10 and PM2.5) were estimated in these two cities. Conditional logistic regression models were employed, adjusting for temperature and humidity. Odds ratios (OR) with 95 % confidence intervals (CI) were expressed relative to an interquartile range increase in the concentration of each pollutant.ResultsNo statistically significant associations were observed for any of the individual pollutants based on same-day, or 1-day lag effects within the Calgary discovery cohort. When the air pollution exposures were assessed as 3-, 5-, and 7-day averages, some pollutants were inversely associated with UGIB in the discovery cohort; for example, 5-day averages of nitrogen dioxide (OR = 0.68; 95 % CI: 0.53–0.88), and particulate matter <2.5 μm (OR = 0.75; 95 % CI: 0.61–0.90). However, these findings could not be reproduced in the replication cohort.ConclusionOur findings suggest that short-term elevations in the level of ambient air pollutants does not increase the incidence of UGIB secondary to PUD.

【 授权许可】

CC BY   
© Quan et al. 2015