Polymorphisms of PTPN11 gene could influence serum lipid levels in a sex-specific pattern

Lipids in Health and Disease

Research

Punyaram Kharbuja¹  Xue-Yuan Cao¹  Zhi-Fang Jia²  Dong-Hui Cao²  Jing Jiang²  Fei Kong² 

[1] Department of Gastrointestinal Surgery, First Hospital of Jilin University, 130021, Changchun, China;Division of Clinical Epidemiology, First Hospital of Jilin University, 130021, Changchun, China;

关键词: PTPN11;    Single nucleotide polymorphism (SNP);    Triglyceride (TG);    Total cholesterol (TC);    Low-density lipoprotein cholesterol (LDL-C);    High-density lipoprotein cholesterol (HDL-C);   

DOI  :  10.1186/1476-511X-12-72

 received in 2013-03-15, accepted in 2013-05-10,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundPrevious studies have reported that different genotypes of PTPN11 gene (protein tyrosine phosphatase, non-receptor 11) were associated with different levels of serum lipids. The aim of this study was to explore the relationship between single nucleotide polymorphisms (SNPs) of PTPN11 and serum lipids in Northeast Chinese.MethodsA total of 1003 subjects, 584 males and 419 females, were included in the study and their serum lipids were determined. Five htSNPs (rs2301756, rs12423190, rs12229892, rs7958372 and rs4767860) of PTPN11 gene were genotyped using TaqMan assay method.ResultsAll of the five SNPs were in Hardy-Weinberg equilibrium. The male subjects had higher triglyceride (TG), higher low-density lipoprotein cholesterol (LDL-C) and lower high-density lipoprotein cholesterol (HDL-C) level than females. In males, rs4767860 was found to be associated with serum TG and total cholesterol (TC) levels and rs12229892 was associated with TC level. However, these significant associations could not be observed in females. In females, rs2301756 was found to be associated with TG and rs7958372 was associated with LDL-C level. Haplotype analysis showed that the GCGTG haplotype was associated with slightly higher TG level and ATGCG with higher TC level.ConclusionsSNPs of PTPN11 may play a role in serum lipids in a sex-specific pattern. However, more studies are needed to confirm the conclusion and explore the underlying mechanism.

【 授权许可】

Unknown   
© Jia et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.