Polymorphisms of PTPN11 gene could influence serum lipid levels in a sex-specific pattern

Lipids in Health and Disease

Jing Jiang¹  Punyaram Kharbuja²  Fei Kong¹  Dong-Hui Cao¹  Xue-Yuan Cao²  Zhi-Fang Jia¹ 

[1] Division of Clinical Epidemiology, First Hospital of Jilin University, Changchun 130021, China;Department of Gastrointestinal Surgery, First Hospital of Jilin University, Changchun 130021, China

关键词: High-density lipoprotein cholesterol (HDL-C);    Low-density lipoprotein cholesterol (LDL-C);    Total cholesterol (TC);    Triglyceride (TG);    Single nucleotide polymorphism (SNP);    PTPN11;   

Others  :  834644
DOI  :  10.1186/1476-511X-12-72

 received in 2013-03-15, accepted in 2013-05-10,  发布年份 2013

【 摘 要 】

Background

Previous studies have reported that different genotypes of PTPN11 gene (protein tyrosine phosphatase, non-receptor 11) were associated with different levels of serum lipids. The aim of this study was to explore the relationship between single nucleotide polymorphisms (SNPs) of PTPN11 and serum lipids in Northeast Chinese.

Methods

A total of 1003 subjects, 584 males and 419 females, were included in the study and their serum lipids were determined. Five htSNPs (rs2301756, rs12423190, rs12229892, rs7958372 and rs4767860) of PTPN11 gene were genotyped using TaqMan assay method.

Results

All of the five SNPs were in Hardy-Weinberg equilibrium. The male subjects had higher triglyceride (TG), higher low-density lipoprotein cholesterol (LDL-C) and lower high-density lipoprotein cholesterol (HDL-C) level than females. In males, rs4767860 was found to be associated with serum TG and total cholesterol (TC) levels and rs12229892 was associated with TC level. However, these significant associations could not be observed in females. In females, rs2301756 was found to be associated with TG and rs7958372 was associated with LDL-C level. Haplotype analysis showed that the GCGTG haplotype was associated with slightly higher TG level and ATGCG with higher TC level.

Conclusions

SNPs of PTPN11 may play a role in serum lipids in a sex-specific pattern. However, more studies are needed to confirm the conclusion and explore the underlying mechanism.

【 授权许可】

   
2013 Jia et al.; licensee BioMed Central Ltd.

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