Effect of plasma lipids, hypertension and APOE genotype on cognitive decline

NEUROBIOLOGY OF AGING

卷:33

Article

Yasuno, Fumihiko^1,2  Tanimukai, Satoshi^2,3  Sasaki, Megumi²  Ikejima, Chiaki²  Yamashita, Fumio^2,4  Kodama, Chiine^2,4  Hidaka, Shin²  Mizukami, Katsuyoshi²  Asada, Takashi² 

[1] Natl Cerebral & Cardiovasc Ctr, Dept Neuropsychiat, Suita, Osaka 5658565, Japan

[2] Univ Tsukuba, Inst Clin Med, Dept Neuropsychiat, Tsukuba, Ibaraki 305, Japan

[3] Ehime Univ, Dept Neuropsychiat, Grad Sch Med, Matsuyama, Ehime 790, Japan

[4] Natl Ctr Neurol & Psychiat, Dept Neuropsychiat, Tokyo, Japan

关键词: Cognitive decline;    APOE genotype;    Hypertension;    Apolipoprotein E (APOE);    High-density lipoprotein (HDL);    Low-density lipoprotein (LDL);    Triglyceride (TG);    Total cholesterol (TC);   

DOI  :  10.1016/j.neurobiolaging.2011.12.028

来源: Elsevier

【 摘 要 】

We examined the combined effect of plasma lipids/hypertension and apolipoprotein E (APOE) genotype on cognitive function in elderly individuals. Plasma concentrations of high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglyceride (TG), total cholesterol (TC), APOE, and history of hypertension were evaluated in 622 community-dwelling individuals aged 65 years and older. We investigated the associations between plasma lipids/hypertension and cognitive function in apolipoprotein E4 allele (APOE4) carrier (E4+) and APOE4 noncarrier (E4-) groups using 3-year longitudinal data. At baseline and 3 years later, cognitive scores were correlated with plasma APOE levels in both E4- and E4+, and HDL level in E4-. The combination of hypertension and E4+, but not E4-, was associated with a significant deterioration in cognitive function during the 3-year follow-up. Our findings suggest that an interaction between APOE and HDL is facilitated by APOE4, and is possibly linked with a protective effect on cognitive decline in later life. The findings also indicate a synergistic effect of an APOE4 allele and hypertension on the acceleration of cognitive decline. (C) 2012 Elsevier Inc. All rights reserved.

【 授权许可】

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