Distribution of ischemic infarction and stenosis of intra- and extracranial arteries in young Chinese patients with ischemic stroke

BMC Cardiovascular Disorders

Research Article

Dongya Huang¹  Ying Li¹  Hedi An¹  Cui Du¹  Nan Shen¹  Zhilan Tu¹  Rong Liu¹  Rajeev Ojha¹ 

[1] Department of Neurology, East Hospital Affiliated to Tongji University School of Medicine, 200120, Shanghai, China;

关键词: Young;    Stroke;    Chinese;    Risk factors;    Carotid stenosis;    Multiple infractions;   

DOI  :  10.1186/s12872-015-0147-5

 received in 2015-07-01, accepted in 2015-11-10,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundThe distribution of cerebral ischemic infarction and stenosis in ischemic stroke may vary with age-group, race and gender. This study was conducted to understand the risk factors and characteristics of cerebral infarction and stenosis of vessels in young Chinese patients with ischemic stroke.MethodsThis was a retrospective study, from January 2007 to July 2012, of 123 patients ≤50 years diagnosed with acute ischemic stroke. Patient characteristics were compared according to sex (98 males and 25 females) and age group (51 patients were ≤45 years and 72 patients were 46–50 years). Characteristics of acute ischemic infarction were studied by diffusion weighted imaging. Stenosis of intra- and extracranial arteries was diagnosed by duplex sonography, head magnetic resonance angiography (MRA) or cervical MRA.ResultsCommon risk factors were hypertension (72.4 %), dyslipidemia (55.3 %), smoking (54.4 %) and diabetes (33.3 %). Lacunar Infarction was most common in our patients (41.5 %). Partial anterior circulation infarction was predominant in females (52.0 vs 32.7 %; P = 0.073) and posterior circulation infarction in males (19.8 vs 4 %; P = 0.073). Multiple brain infarctions were found in 38 patients (30.9 %). Small artery atherosclerosis was found in 54 patients (43.9 %), with higher prevalence in patients of the 46–50 years age-group. Intracranial stenosis was more common than extracranial stenosis, and middle cerebral artery stenosis was most prevalent (27.3 %). Stenosis in the anterior circulation was more frequent than in the posterior circulation (P < 0.001).ConclusionsIn these young patients, hypertension, smoking, dyslipidemia and diabetes were common risk factors. Intracranial stenosis was most common. The middle cerebral artery was highly vulnerable.

【 授权许可】

CC BY   
© Ojha et al. 2015