Distribution of ischemic infarction and stenosis of intra- and extracranial arteries in young Chinese patients with ischemic stroke

BMC Cardiovascular Disorders

Ying Li¹  Zhilan Tu¹  Nan Shen¹  Cui Du¹  Rong Liu¹  Hedi An¹  Dongya Huang¹  Rajeev Ojha¹ 

[1] Department of Neurology, East Hospital Affiliated to Tongji University School of Medicine, Shanghai 200120, China

关键词: Multiple infractions;    Carotid stenosis;    Risk factors;    Chinese;    Stroke;    Young;   

Others  :  1234491
DOI  :  10.1186/s12872-015-0147-5

 received in 2015-07-01, accepted in 2015-11-10,  发布年份 2015

【 摘 要 】

Background

The distribution of cerebral ischemic infarction and stenosis in ischemic stroke may vary with age-group, race and gender. This study was conducted to understand the risk factors and characteristics of cerebral infarction and stenosis of vessels in young Chinese patients with ischemic stroke.

Methods

This was a retrospective study, from January 2007 to July 2012, of 123 patients ≤50 years diagnosed with acute ischemic stroke. Patient characteristics were compared according to sex (98 males and 25 females) and age group (51 patients were ≤45 years and 72 patients were 46–50 years). Characteristics of acute ischemic infarction were studied by diffusion weighted imaging. Stenosis of intra- and extracranial arteries was diagnosed by duplex sonography, head magnetic resonance angiography (MRA) or cervical MRA.

Results

Common risk factors were hypertension (72.4 %), dyslipidemia (55.3 %), smoking (54.4 %) and diabetes (33.3 %). Lacunar Infarction was most common in our patients (41.5 %). Partial anterior circulation infarction was predominant in females (52.0 vs 32.7 %; P = 0.073) and posterior circulation infarction in males (19.8 vs 4 %; P = 0.073). Multiple brain infarctions were found in 38 patients (30.9 %). Small artery atherosclerosis was found in 54 patients (43.9 %), with higher prevalence in patients of the 46–50 years age-group. Intracranial stenosis was more common than extracranial stenosis, and middle cerebral artery stenosis was most prevalent (27.3 %). Stenosis in the anterior circulation was more frequent than in the posterior circulation (P < 0.001).

Conclusions

In these young patients, hypertension, smoking, dyslipidemia and diabetes were common risk factors. Intracranial stenosis was most common. The middle cerebral artery was highly vulnerable.

【 授权许可】

   
2015 Ojha et al.

【 图 表 】

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