Risks associated with endotoxins in feed additives produced by fermentation

Environmental Health

Review

Paul G. Brantom¹  Noël Dierick²  Lucio G. Costa³  Giovanna Martelli⁴  Vasileios Bampidis⁵  Derek W. Renshaw⁶  Lubomir Leng⁷  R. John Wallace⁸  Jürgen Gropp⁹ 

[1] Brantom Risk Assessment Ltd, Crawley, UK;Department of Animal Production, Ghent University, Ghent, Belgium;Department of Neuroscience, University of Parma, Parma, Italy;Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA;Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy;Division of Animal Production, Department of Agricultural Technology, School of Agricultural Technology, Food Technology and Nutrition, Alexander Technological Educational Institute (ATEITHE), 57400, Thessaloniki, Greece;Independent consultant on toxicology, Ladywell, London, UK;Institute of Animal Physiology, Slovak Academy of Sciences, Kosice, Slovakia;Rowett Institute of Nutrition and Health, University of Aberdeen, Bucksburn, AB21 9SB, Aberdeen, UK;Universität Leipzig, Leipzig, Germany;

关键词: Endotoxin;    Feed additives;    Lipopolysaccharide;    Worker exposure;   

DOI  :  10.1186/s12940-016-0087-2

 received in 2015-07-09, accepted in 2016-01-10,  发布年份 2016

来源: Springer

【 摘 要 】

Increasingly, feed additives for livestock, such as amino acids and vitamins, are being produced by Gram-negative bacteria, particularly Escherichia coli. The potential therefore exists for animals, consumers and workers to be exposed to possibly harmful amounts of endotoxin from these products. The aim of this review was to assess the extent of the risk from endotoxins in feed additives and to calculate how such risk can be assessed from the properties of the additive. Livestock are frequently exposed to a relatively high content of endotoxin in the diet: no additional hazard to livestock would be anticipated if the endotoxin concentration of the feed additive falls in the same range as feedstuffs. Consumer exposure will be unaffected by the consumption of food derived from animals receiving endotoxin-containing feed, because the small concentrations of endotoxin absorbed do not accumulate in edible tissues. In contrast, workers processing a dusty additive may be exposed to hazardous amounts of endotoxin even if the endotoxin concentration of the product is low. A calculation method is proposed to compare the potential risk to the worker, based on the dusting potential, the endotoxin concentration and technical guidance of the European Food Safety Authority, with national exposure limits.

【 授权许可】

CC BY   
© Wallace et al. 2016