Combined epithelial-mesenchymal transition with cancer stem cell-like marker as predictors of recurrence after radical resection for gastric cancer

World Journal of Surgical Oncology

Research

Gui-fang Xu¹  Xiaoping Zou²  Wei-jie Zhang³  Wenxian Guan³  Qi Sun⁴  Xinyun Xu⁴ 

[1] Department of Gastroenterology, Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, 210008, Nanjing, China;Department of General Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, 210008, Nanjing, China;Department of General Surgery, Drum Tower Clinical College of Nanjing Medical University, 321 Zhongshan Road, 210008, Nanjing, China;Department of General Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, 210008, Nanjing, China;Department of Pathology, Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, 210008, Nanjing, China;

关键词: Gastric Cancer;    Cancer Stem Cell;    Early Recurrence;    Recurrence Pattern;    Late Recurrence;   

DOI  :  10.1186/1477-7819-12-368

 received in 2014-06-13, accepted in 2014-11-18,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThe aim of the study was to identify the incidence and the predictors of recurrence after curative resection and the clinical significance of epithelial-mesenchymal transition (EMT) and stem cell-like phenotypes in gastric cancer.MethodsIn a total of 1,463 patients that underwent curative resection for gastric cancer between January 2001 and January 2008 at Drum Tower Hospital, 402 (27.5%) experienced recurrence. They were divided into early recurrence (within two years) and late recurrence (more than two years). The clinicopathological characteristics, including five EMT-related proteins (Snail-1, ZEB-1, E-cadherin, vimentin, and β-catenin) and the gastric cancer stem cell markers CD44 and CD54, therapeutic modalities, survival time after recurrence, and recurrence patterns were compared between the two groups.ResultsLoss of E-cadherin expression and aberrant expression of vimentin and the known gastric cancer stem cell maker CD44 were significantly associated with aggressive clinicopathologic features. Multivariate analysis showed that stage III gastric cancer patients with early recurrence had larger tumors and more lymph node metastasis, coupled with aberrant expression EMT and cancer stem cell marker, than patients with late recurrence. Early recurrence was associated with more distant metastasis than late recurrence and patients tended to die within two years of recurrence.ConclusionsCombined EMT with cancer stem cell-like marker is a predictor of recurrence after radical resection for gastric cancer. Advanced TNM stage was associated with early cancer death after recurrence.

【 授权许可】

Unknown   
© Xu et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.