Aberrant expression of CD133 protein correlates with Ki-67 expression and is a prognostic marker in gastric adenocarcinoma

BMC Cancer

Research Article

Yazhuo Li¹  Po Zhao¹  Yali Lu¹ 

[1] Department of Pathology, Chinese People's Liberation Army General Hospital, 100853, Beijing, China;

关键词: Gastric Cancer;    CD133 Expression;    Cancer Stem Cell;    Gastric Cancer Cell;    Gastric Adenocarcinoma;   

DOI  :  10.1186/1471-2407-10-218

 received in 2010-02-02, accepted in 2010-05-20,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundThe relationships between the expression of CD133, Ki-67 and prognosis in gastric adenocarcinoma are unknown and needs exploring.MethodsThe samples of gastric adenocarcinoma from 336 Chinese patients with follow-up were analyzed for CD133 and Ki-67 protein expressions by immunohistochemical method.ResultsCD133 was expressed in up to 57.4% (193/336) of this group of gastric carcinoma. The expression of CD133 was significantly higher in carcinoma than in normal (P = 0.0001) and dysplastic mucosas (P = 0.004). CD133 was positive corresponded with the tumour size, grade, infiltrative depth and clinical stage (all P < 0.05). The overall mean survival time of the patients with CD133 positive expression was shorter than that of patients with negative expression (P = 0.0001). The expression of CD133 has a positive correlation with that of Ki-67 (r = 0.188, P = 0.001) in gastric adenocarcinoma. CD133 was an independent prognostic indicator. (P = 0.0001).ConclusionsIt is suggested that CD133 may play an important role in the evolution of gastric adenocarcinoma and should be considered as a potential marker for the prognosis.

【 授权许可】

CC BY   
© Zhao et al; licensee BioMed Central Ltd. 2010