Differentiating the impact of anatomic and non-anatomic liver resection on early recurrence in patients with Hepatocellular Carcinoma

World Journal of Surgical Oncology

Research

Ahmed H Helmy¹  Francesco Giovinazzo²  Ronald R Salem²  Mark Kidd²  Karim M Eltawil³ 

[1] Department of Surgery, Theodor Bilharz Research Institute, Cairo, Egypt;Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, USA;Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, USA;Department of Surgery, Theodor Bilharz Research Institute, Cairo, Egypt;

关键词: Liver Resection;    Hepatic Resection;    Early Recurrence;    Anatomic Resection;    Microscopic Vascular Invasion;   

DOI  :  10.1186/1477-7819-8-43

 received in 2010-03-07, accepted in 2010-05-24,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundFor Hepatocellular Carcinoma (HCC) treated with hepatectomy, the extent of the resection margin remains controversial and data available on its effect on early tumor recurrence are very few and contradictory. The purpose of this study was to compare the impact of the type of resection (anatomic versus non-anatomic) on early intra-hepatic HCC recurrence in patients with solitary HCC and preserved liver function.MethodsAmong 53 patients with similar clinico-pathologic data who underwent curative liver resection for HCC between 2000 and 2006, 28 patients underwent anatomic resection of at least one liver segment and 25 patients underwent limited resection with a margin of at least 1 cm.ResultsAfter a close follow-up period of 24 months, no difference was detected in recurrence rates between the anatomic (35.7%) and the non-anatomic (40%) groups in either univariate (p = 0.74) and multivariate (p = 0.65) analysis. Factors contributing to early recurrence were tumor size (p = 0.012) and tumor stage including vascular invasion (p = 0.009).ConclusionThe choice of the type of resection for HCC should be based on the maintenance of adequate hepatic reserve. The type of resection (anatomic vs non-anatomic) was found not to be a risk factor for early tumor recurrence.

【 授权许可】

Unknown   
© Eltawil et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.