Anemia and risk for cognitive decline in chronic kidney disease

BMC Nephrology

Research Article

Eric Vittinghoff¹  Kristine Yaffe²  Vecihi Batuman³  James Lash⁴  Stephen L. Seliger⁵  Debbie L. Cohen⁶  James Simon⁷  Juan Ordonez⁸  Jingrong Yang⁹  Alan S. Go^1,10  John W. Kusek^1,11  Gail Makos^1,12  Manjula Kurella Tamura^1,13 

[1] Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA;Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA;Departments of Psychiatry and Neurology, University of California San Francisco, San Francisco, CA, USA;Department of Medicine, Tulane University Medical School, New Orleans, LA, USA;Department of Medicine, University of Illinois Chicago, Chicago, IL, USA;for the CRIC Study Investigators, Philadelphia, PA, USA;Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA;Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA;Department of Nephrology and Hypertension, Glickman Urologic and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA;Division of Nephrology, Kaiser Permanente Northern California, Oakland, CA, USA;Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA;Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA;for the CRIC Study Investigators, Philadelphia, PA, USA;National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA;for the CRIC Study Investigators, Philadelphia, PA, USA;St. John Providence Medical Center, Detroit, MI, USA;VA Palo Alto Geriatric Research and Education Clinical Center, 3801 Miranda Ave., 94304, Palo Alto, CA, USA;Division of Nephrology, Stanford University School of Medicine, Palo Alto, CA, USA;

关键词: Cognitive decline;    CKD;    Anemia;   

DOI  :  10.1186/s12882-016-0226-6

 received in 2015-10-15, accepted in 2016-01-20,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundAnemia is common among patients with chronic kidney disease (CKD) but its health consequences are poorly defined. The aim of this study was to determine the relationship between anemia and cognitive decline in older adults with CKD.MethodsWe studied a subgroup of 762 adults age ≥55 years with CKD participating in the Chronic Renal Insufficiency Cohort (CRIC) study. Anemia was defined according to the World Health Organization criteria (hemoglobin <13 g/dL for men and <12 g/dL for women). Cognitive function was assessed annually with a battery of six tests. We used logistic regression to determine the association between anemia and baseline cognitive impairment on each test, defined as a cognitive score more than one standard deviation from the mean, and mixed effects models to determine the relation between anemia and change in cognitive function during follow-up after adjustment for demographic and clinical characteristics.ResultsOf 762 participants with mean estimated glomerular filtration rate of 42.7 ± 16.4 ml/min/1.73 m2, 349 (46 %) had anemia. Anemia was not independently associated with baseline cognitive impairment on any test after adjustment for demographic and clinical characteristics. Over a median 2.9 (IQR 2.6–3.0) years of follow-up, there was no independent association between anemia and change in cognitive function on any of the six cognitive tests.ConclusionsAmong older adults with CKD, anemia was not independently associated with baseline cognitive function or decline.

【 授权许可】

CC BY   
© Kurella Tamura et al. 2016