Associations between renal impairment and anemia in older, rural Japanese men: the Nagasaki Island study

Journal of Physiological Anthropology

Takahiro Maeda²  Noboru Takamura⁷  Yosuke Kusano⁵  Hironori Yamasaki⁴  Kazuhiko Arima⁶  Mami Tamai¹  Koichiro Kadota³  Mako Nagayoshi³  Hirotomo Yamanashi²  Jun Koyamatsu²  Shimpei Sato³  Yuji Shimizu³ 

[1] Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan;Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan;Department of Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan;Center for Health and Community Medicine, Nagasaki University, Nagasaki, Japan;Department of Internal Medicine, Nagasaki National Hospital, Nagasaki, Japan;Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan;Department of Global Health, Medicine and Welfare, Nagasaki University Graduate School of Biomedical Sciences, Atomic Bomb Disease Institute, Nagasaki, Japan

关键词: Men;    CKD;    Renal impairments;    Anemia;    GFR;   

Others  :  861443
DOI  :  10.1186/1880-6805-33-7

 received in 2013-12-13, accepted in 2014-04-02,  发布年份 2014

【 摘 要 】

Background

Renal impairment is known to be associated with atherosclerosis, which in turn is reported to be positively associated with hemoglobin levels. In addition, renal impairment is known to be associated with a form of anemia known as renal anemia.

Methods

To clarify the associations between renal impairment and anemia, we conducted a cross-sectional study of 1,105 60 to 89-year-old men, who were not taking medication for anemia and were undergoing general health check-ups.

Results

Compared with non-chronic kidney disease, chronic kidney disease (CKD) with a glomerular filtration rate (GFR) <60 mL/min/1.73 m² was found to constitute a significant risk of anemia. However, we noted that this risk was lower for mild renal impairment (60 mL/min/1.73 m² ≤ GFR <90 mL/min/1.73 m²). Compared with the non-CKD reference group, the classical cardiovascular risk factors adjusted odds ratio (OR) for anemia was 1.81 (1.23 to 2.68) and compared with the normal renal function (GFR ≥90 mL/min/1.73 m²) reference group, the ORs for mild renal impairment and CKD were 0.26 (0.15 to 0.47) and 0.60 (0.33 to 1.09).

Conclusions

Independent from classical cardiovascular risk factors, CKD, which was identified during general health check-ups, appeared to constitute a significant risk of anemia for older Japanese men. For mild renal impairment, however, this association was a reduced risk of anemia and thus possibly a higher risk of atherosclerosis.

【 授权许可】

   
2014 Shimizu et al.; licensee BioMed Central Ltd.

【 图 表 】

【 参考文献 】

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