Adjusted color probability codes for peripapillary retinal nerve fiber layer thickness in healthy Koreans

BMC Ophthalmology

Research Article

Samin Hong¹  Sang-Myung Kim¹  Gong Je Seong¹  Chan Yun Kim¹  Kyoungsoo Park²  Jun Mo Lee² 

[1] Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, 50 Yonsei-ro, 120-752, Seodaemun-gu, Seoul, Republic of Korea;Siloam Eye Hospital, Seoul, Republic of Korea;

关键词: Glaucoma;    Optical coherence tomography;    Probability code;    Retinal nerve fiber layer;   

DOI  :  10.1186/1471-2415-14-38

 received in 2013-12-10, accepted in 2014-03-26,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThough a newly developed spectral domain optical coherence tomography (OCT) is at the center of interests for many ophthalmologic researchers and clinicians, its own characteristics are not fully evaluated yet. The main purpose of this study was to establish the adjusted color probability codes for peripapillary retinal nerve fiber layer (RNFL) thickness in healthy Koreans and to compare them with original color codes provided by spectral domain OCT.MethodsTwo hundred ninety-five healthy Korean eyes were enrolled and their peripapillary RNFL thickness was measured by Cirrus OCT. For each decade of age, the normal thickness reference was determined on the basis of z-scores and the adjusted color probability codes were established. Then the agreements between adjusted and original color codes were calculated using weighted Kappa (Kw) coefficient.ResultsOn the basis of Kw coefficient, the overall agreement between the adjusted and original probability color codes was not excellent (Kw range of 0.500 to 0.806). If the adjusted probability codes were assumed as a standard of comparison, the original color codes showed the false-negative in 11% of eyes and the false-positive in 0.3% of eyes for average RNFL thickness.ConclusionsAdjusted color probability codes judged by the Korean normative data showed a discrepancy with original codes. It implies that normal reference and adjusted probability codes for each ethnicity might be needed to determine whether a certain RNFL thickness is within normal range or not.

【 授权许可】

Unknown   
© Hong et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.