Ischemic aetiology, self-reported frailty, and gender with respect to cognitive impairment in chronic heart failure patients

BMC Cardiovascular Disorders

Research Article

María J González-Moneo¹  José M Verdu-Rotellar¹  Mercé Cladellas²  Cristina Enjuanes²  Josep Comín-Colet²  Jordi Bruguera²  Sonia Quiñones-Ubeda³  Jordi Peña-Casanova³  Gonzalo Sánchez-Benavides³ 

[1] Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain;Grup de recerca biomedica en malalties del cor GREC (Heart Diseases Biomedical Research Group), IMIM (Hospital del Mar Medical Research Institute), 88, Doctor Aiguader, 08003, Barcelona, Spain;San Martin Primary Care Center, Barcelona, Spain;Jordi Gol University Institute for Research Primary Healthcare, Barcelona, Spain;Grup de recerca biomedica en malalties del cor GREC (Heart Diseases Biomedical Research Group), IMIM (Hospital del Mar Medical Research Institute), 88, Doctor Aiguader, 08003, Barcelona, Spain;Neurofunctionality of Brain and Language Group, Neurosciences Research Programme, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain;

关键词: Heart failure;    Cognitive symptoms;    Prevalence;    Comorbidity;   

DOI  :  10.1186/s12872-016-0349-5

 received in 2016-01-21, accepted in 2016-08-19,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundDecisive information on the parameters involved in cognitive impairment in patients with chronic heart failure is as yet lacking. Our aim was to determine the functional and psychosocial variables related with cognitive impairment using the mini-mental-state examination (MMSE) with age-and education-corrected scores.MethodsA cohort study of chronic heart failure patients included in an integrated multidisciplinary hospital/primary care program. The MMSE (corrected for age and education in the Spanish population) was administered at enrolment in the program. Analyses were performed in 525 patients. Demographic and clinical variables were collected. Comprehensive assessment included depression (Yesavage), family function (family APGAR), social network (Duke), dependence (Barthel Index), frailty (Barber), and comorbidities. Univariate and multivariate logistic regression were performed to determine the predictors of cognitive impairment.ResultsCognitive impairment affected 145 patients (27.6 %). Explanatory factors were gender (OR: 2.77 (1.75–4.39) p < 0.001), ischemic etiology (OR: 1.99 (1.25–3.17) p = 0.004), frailty (OR: 1.58 (0.99 to 2.50, p =0.050), albumin > 3.5 (OR: 0.59 (0.35–0.99) p = 0.048), and beta-blocker treatment (OR: 0.36 (0.17 to 0.76, p = 0.007)). No association was found between cognitive impairment and social support or family function.ConclusionThe observed prevalence of cognitive impairment using MMSE corrected scores was 27.6 %. A global approach in the management of these patients is needed, especially focusing on women and patients with frailty, low albumin levels, and ischemic aetiology heart failure.

【 授权许可】

CC BY   
© The Author(s). 2016