Impact of MBL and MASP-2 gene polymorphism and its interaction on susceptibility to tuberculosis

BMC Infectious Diseases

Research Article

Xin Huang¹  Hongzhuan Tan¹  Mian Wang¹  Li Hu²  Benjamin Kwaku Abuaku³  Shi Wu Wen⁴  Mengshi Chen⁵  Ying Liang⁶  Wufei Li⁷ 

[1] Department of Epidemiology and Health Statistics, School of Public Health, Central South University, 410008, Changsha, Hunan, PR China;Department of Epidemiology and Health Statistics, School of Public Health, Central South University, 410008, Changsha, Hunan, PR China;Beijing Center for Diseases Prevention and Control, 100013, Beijing, PR China;Department of Epidemiology and Health Statistics, School of Public Health, Central South University, 410008, Changsha, Hunan, PR China;Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, PO Box LG581, Legon, Accra, Ghana;Department of Epidemiology and Health Statistics, School of Public Health, Central South University, 410008, Changsha, Hunan, PR China;Department of Obstetrics & Gynecology, University of Ottawa, The Ottawa Hospital, 501 Smyth Road, Ottawa, Ontario, Canada;Department of Epidemiology and Health Statistics, School of Public Health, Central South University, 410008, Changsha, Hunan, PR China;Hunan Children’s Hospital, Ziyuan RD 86, 410007, Changsha, Hunan, PR China;Department of Epidemiology and Health Statistics, School of Public Health, Central South University, 410008, Changsha, Hunan, PR China;School of Public Health, Xinjiang Medical University, 830054, Urumqi, Xijiang, PR China;Department of Nursing, Shaoyang Medical College, 422000, Shaoyang, Hunan, PR China;

关键词: Tuberculosis;    MBL;    MASP-2;    Gene;    Interaction;    RERI;   

DOI  :  10.1186/s12879-015-0879-y

 received in 2014-01-08, accepted in 2015-03-10,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundMannose-binding lectin (MBL) and MBL-associated serine proteases 2 (MASP-2) are important proteins in the lectin pathway of the immune system. Polymorphism of MBL and MASP-2 genes may affect the serum concentration of MBL and MASP-2. This study explores the association between MBL and MASP-2 gene polymorphism and their interactions and the susceptibility to tuberculosis (TB).MethodA total of 503 patients with TB and 419 healthy controls were recruited to participate in this case-control study. PCR-SSP technology was applied to genotype rs7096206 of MBL genes and rs2273346 and rs6695096 of MASP-2 genes. Demographic data and some exposure information were also obtained from study participants. Unconditional logistic regression analysis was used to identify association between the various factors and TB whilst Marginal Structural Linear Odds Models were used to estimate the interactions.ResultsBoth genotype GC at rs7096206 of MBL genes and genotype TC at rs2273346 and rs6695096 of MASP-2 genes were more prevalent in the TB patient group than the healthy control group (P < 0.05, OR 1.393, 1.302 and 1.426 respectively). The relative excess risk of interaction (RERI) between rs7096206 of MBL genes and rs2273346 and rs6695096 of MASP-2 genes was 0.897 (95% CI: 0.282, 1.513) and 1.142 (95% CI: 0.755, 1.530) respectively (P < 0.05).ConclusionPolymorphisms of MBL (rs7096206) and MASP-2 (rs2273346 and rs6695096) were associated with the susceptibility of TB, and there were gene-gene interactions among them.

【 授权许可】

Unknown   
© Chen et al.; licensee BioMed Central. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.