HOX-7 suppresses body weight gain and adipogenesis-related gene expression in high-fat-diet-induced obese mice

BMC Complementary and Alternative Medicine

Research Article

Sung-Kew Kim¹  Chang-Hyun Oh¹  Kyung Ho Yoo²  Jong-Sik Jin³  Hong-Kun Rim⁴  Jong-Hwan Seo⁴  Hyo-Jin An⁴  Heon-Myung Lee⁴  Yoon-Bum Kook⁵ 

[1] Center for Biomaterials, Korea Institute of Science and Technology (KIST), PO Box 131, 130-650, Cheongryang, Seoul, Republic of Korea;Chemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), PO Box 131, 130-650, Cheongryang, Seoul, Republic of Korea;Department of Oriental Medicine Resources, College of Environmental & Bioresources Sciences, Chonbuk National University, Jeonju, Jeonbuk, Republic of Korea;Department of Pharmacology, College of Oriental Medicine, Sangji University, 220-702, Wonju-si, Gangwon-do, Republic of Korea;Department of Presctiption, College of Oriental Medicine, Sangji University, 220-702, Wonju-si, Gangwon-do, Republic of Korea;

关键词: C/EBPα;    Mice;    Obesity;    PPARγ;    SREBP1c;    Traditional herbal medicine;   

DOI  :  10.1186/1472-6882-14-505

 received in 2014-09-23, accepted in 2014-12-09,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundHOX-7 is a newly developed dietary formula composed of traditional oriental herbal medicines. The formula was developed with the aim of improving weight control. We investigated the anti-obesity effect of HOX-7 on high-fat-diet (HFD)-induced obesity in C57BL/6 mice.MethodsThe mice were divided into four groups and were fed a normal diet (ND), HFD, or HFD with oral administration of HOX-7 at 100 or 200 mg/kg/day for 12 weeks. Body and fat weight, histological changes of fat tissue, and the expression of key adipogenic transcription factors were investigated.ResultsThe body weight of mice fed the HFD with HOX-7 was significantly decreased compared to the HFD group. There were no obvious differences in weekly food intake among the 4 groups. The weight of the epididymal and total fat pads was reduced in mice fed the HFD with HOX-7. Treatment with HOX-7 also substantially attenuated the expression of key adipogenic transcription factors, including peroxisome proliferatoractivated receptor γ, CCAAT/enhancer binding protein α, sterol regulatory element binding protein 1c, adipocyte P2, liver X receptor, and lipoprotein lipase in the epididymal adipose tissue.ConclusionOverall, this study highlighted the anti-obesity effects of HOX-7, a finding that could contribute to the development of natural anti-obesity herbal medicines.

【 授权许可】

Unknown   
© Lee et al.; licensee BioMed Central. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.