HOX-7 suppresses body weight gain and adipogenesis-related gene expression in high-fat-diet-induced obese mice

BMC Complementary and Alternative Medicine

Hyo-Jin An⁵  Jong-Sik Jin¹  Kyung Ho Yoo³  Chang-Hyun Oh⁴  Sung-Kew Kim⁴  Yoon-Bum Kook²  Jong-Hwan Seo⁵  Hong-Kun Rim⁵  Heon-Myung Lee⁵ 

[1] Department of Oriental Medicine Resources, College of Environmental & Bioresources Sciences, Chonbuk National University, Jeonju, Jeonbuk, Republic of Korea;Department of Presctiption, College of Oriental Medicine, Sangji University, Wonju-si, Gangwon-do 220-702, Republic of Korea;Chemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), PO Box 131, Cheongryang, Seoul 130-650, Republic of Korea;Center for Biomaterials, Korea Institute of Science and Technology (KIST), PO Box 131, Cheongryang, Seoul 130-650, Republic of Korea;Department of Pharmacology, College of Oriental Medicine, Sangji University, Wonju-si, Gangwon-do 220-702, Republic of Korea

关键词: Traditional herbal medicine;    SREBP1c;    PPARγ;    Obesity;    Mice;    C/EBPα;   

Others  :  1084611
DOI  :  10.1186/1472-6882-14-505

 received in 2014-09-23, accepted in 2014-12-09,  发布年份 2014

【 摘 要 】

Background

HOX-7 is a newly developed dietary formula composed of traditional oriental herbal medicines. The formula was developed with the aim of improving weight control. We investigated the anti-obesity effect of HOX-7 on high-fat-diet (HFD)-induced obesity in C57BL/6 mice.

Methods

The mice were divided into four groups and were fed a normal diet (ND), HFD, or HFD with oral administration of HOX-7 at 100 or 200 mg/kg/day for 12 weeks. Body and fat weight, histological changes of fat tissue, and the expression of key adipogenic transcription factors were investigated.

Results

The body weight of mice fed the HFD with HOX-7 was significantly decreased compared to the HFD group. There were no obvious differences in weekly food intake among the 4 groups. The weight of the epididymal and total fat pads was reduced in mice fed the HFD with HOX-7. Treatment with HOX-7 also substantially attenuated the expression of key adipogenic transcription factors, including peroxisome proliferatoractivated receptor γ, CCAAT/enhancer binding protein α, sterol regulatory element binding protein 1c, adipocyte P2, liver X receptor, and lipoprotein lipase in the epididymal adipose tissue.

Conclusion

Overall, this study highlighted the anti-obesity effects of HOX-7, a finding that could contribute to the development of natural anti-obesity herbal medicines.

【 授权许可】

   
2014 Lee et al.; licensee BioMed Central.

【 图 表 】

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