Disorder-specific cognitive profiles in major depressive disorder and generalized anxiety disorder

BMC Psychiatry

Research Article

Sanne M Hendriks¹  Florian Hardeveld¹  Carmilla MM Licht²  Aartjan TF Beekman²  Brenda WJH Penninx³  Ron de Graaf⁴  Jan Spijker⁵ 

[1] Department of Psychiatry, Pro Persona Mental Health Care, Willy Brandtlaan 20, 6717 RR, Ede, The Netherlands;Department of Psychiatry, VU University Amsterdam, A.J. Ernststraat 887, 1081 HL, Amsterdam, The Netherlands;Department of Psychiatry, VU University Amsterdam, A.J. Ernststraat 887, 1081 HL, Amsterdam, The Netherlands;Department of Psychiatry, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands;Department of Psychiatry, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands;Netherlands Institute of Mental Health and Addiction, Da Costakade 45, 3521 VS, Utrecht, The Netherlands;Pro Persona Mental Health Care, Radboud University Nijmegen, Reinier Postlaan 6, 6525 GC, Nijmegen, The Netherlands;Netherlands Institute of Mental Health and Addiction, Da Costakade 45, 3521 VS, Utrecht, The Netherlands;

关键词: Major depressive disorder;    Generalized anxiety disorder;    Cognitive profiles;    Treatment;    Classification;   

DOI  :  10.1186/1471-244X-14-96

 received in 2013-01-23, accepted in 2014-03-25,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThis investigation examines differences in cognitive profiles in subjects with major depressive disorder (MDD) and generalized anxiety disorder (GAD).MethodsData were used from subjects with current MDD (n = 655), GAD (n = 107) and comorbid MDD/GAD (n = 266) diagnosis from the Netherlands Study of Depression and Anxiety (NESDA). The Composite Interview Diagnostic Instrument was used to diagnose MDD and GAD. Cognitive profiles were measured using the Leiden Index of Depression Sensitivity, the Anxiety Sensitivity Index, and the Penn State Worry Questionnaire.ResultsResults showed that differences in cognitive profiles between single MDD and single GAD subjects were present: scores on hopelessness/suicidality and rumination were significantly higher in MDD than GAD, whereas anxiety sensitivity for physical concerns and pathological worry were higher in GAD than MDD. The cognitive profile of comorbid MDD/GAD showed more extreme depression cognitions compared to single disorders, and a similar anxiety profile compared to single GAD subjects.ConclusionsDespite the commonalities in cognitive profiles in MDD and GAD, there are differences suggesting that MDD and GAD have disorder-specific cognitive profiles. Findings of this investigation give support for models like the cognitive content-specificity model and the tripartite model and could provide useful handles for treatment focus.

【 授权许可】

CC BY   
© Hendriks et al.; licensee BioMed Central Ltd. 2014