Disorder-specific cognitive profiles in major depressive disorder and generalized anxiety disorder

BMC Psychiatry

Brenda WJH Penninx²  Ron de Graaf¹  Florian Hardeveld³  Aartjan TF Beekman⁴  Jan Spijker¹  Carmilla MM Licht⁴  Sanne M Hendriks³ 

[1] Netherlands Institute of Mental Health and Addiction, Da Costakade 45, Utrecht 3521 VS, The Netherlands;Department of Psychiatry, University Medical Center Groningen, Hanzeplein 1, Groningen 9713 GZ, The Netherlands;Department of Psychiatry, Pro Persona Mental Health Care, Willy Brandtlaan 20, Ede 6717 RR, The Netherlands;Department of Psychiatry, VU University Amsterdam, A.J. Ernststraat 887, Amsterdam 1081 HL, The Netherlands

关键词: Classification;    Treatment;    Cognitive profiles;    Generalized anxiety disorder;    Major depressive disorder;   

Others  :  1123669
DOI  :  10.1186/1471-244X-14-96

 received in 2013-01-23, accepted in 2014-03-25,  发布年份 2014

【 摘 要 】

Background

This investigation examines differences in cognitive profiles in subjects with major depressive disorder (MDD) and generalized anxiety disorder (GAD).

Methods

Data were used from subjects with current MDD (n = 655), GAD (n = 107) and comorbid MDD/GAD (n = 266) diagnosis from the Netherlands Study of Depression and Anxiety (NESDA). The Composite Interview Diagnostic Instrument was used to diagnose MDD and GAD. Cognitive profiles were measured using the Leiden Index of Depression Sensitivity, the Anxiety Sensitivity Index, and the Penn State Worry Questionnaire.

Results

Results showed that differences in cognitive profiles between single MDD and single GAD subjects were present: scores on hopelessness/suicidality and rumination were significantly higher in MDD than GAD, whereas anxiety sensitivity for physical concerns and pathological worry were higher in GAD than MDD. The cognitive profile of comorbid MDD/GAD showed more extreme depression cognitions compared to single disorders, and a similar anxiety profile compared to single GAD subjects.

Conclusions

Despite the commonalities in cognitive profiles in MDD and GAD, there are differences suggesting that MDD and GAD have disorder-specific cognitive profiles. Findings of this investigation give support for models like the cognitive content-specificity model and the tripartite model and could provide useful handles for treatment focus.

【 授权许可】

   
2014 Hendriks et al.; licensee BioMed Central Ltd.

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