Disorder- and emotional context-specific neurofunctional alterations during inhibitory control in generalized anxiety and major depressive disorder

NeuroImage: Clinical

Jinyu Wang¹  Yuanshu Chen¹  Huafu Chen²  Bo Zhou²  Benjamin Becker²  Xiaolei Xu³  Zhili Zou³  Keith M. Kendrick³  Fei Xin⁴  Ziyu Qi⁴  Feng Zhou⁴  Yulan Huang⁴  Xinqi Zhou⁴  Lizhu Luo⁴  Congcong Liu⁴  Jing Dai⁴  Qian Zhuang⁴ 

[1] Chengdu Mental Health Center, Chengdu, Sichuan 610036, China;Sichuan Provincial People’s Hospital, Chengdu, Sichuan 610072, China;;Department of Psychosomatic Medicine, Sichuan Academy of Medical Sciences &The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for NeuroInformation, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China;

关键词: Generalized anxiety disorder;    Major depressive disorder;    Biomarker;    Emotion;    Inhibitory control;   

DOI  :  

来源: DOAJ

【 摘 要 】

Major Depressive Disorder (MDD) and Generalized Anxiety Disorder (GAD) are highly debilitating and often co-morbid disorders. The disorders exhibit partly overlapping dysregulations on the behavioral and neurofunctional level. The determination of disorder-specific behavioral and neurofunctional dysregulations may therefore promote neuro-mechanistic and diagnostic specificity. In order to determine disorder-specific alterations in the domain of emotion-cognition interactions the present study examined emotional context-specific inhibitory control in treatment-naïve MDD (n = 37) and GAD (n = 35) patients and healthy controls (n = 35). On the behavioral level MDD but not GAD exhibited impaired inhibitory control irrespective of emotional context. On the neural level, MDD-specific attenuated recruitment of inferior/medial parietal, posterior frontal, and mid-cingulate regions during inhibitory control were found during the negative context. GAD exhibited a stronger engagement of the left dorsolateral prefrontal cortex relative to MDD. Overall the findings from the present study suggest disorder- and emotional context-specific behavioral and neurofunctional inhibitory control dysregulations in major depression and may point to a depression-specific neuropathological and diagnostic marker.

【 授权许可】

Unknown