100 million years of multigene family evolution: origin and evolution of the avian MHC class IIB

BMC Genomics

Research Article

Francesco Bonadonna¹  Maria Strandh²  Reto Burri³  Marta Promerová⁴  Glenn Yannic⁵  Julien Goebel⁶  Luca Fumagalli⁶  Céline Serbielle⁷  Karen D. McCoy⁷ 

[1] CNRS, UMR 5175, Centre for Functional and Evolutionary Ecology, F-34293, Montpellier, France;CNRS, UMR 5175, Centre for Functional and Evolutionary Ecology, F-34293, Montpellier, France;Present address: Molecular Ecology and Evolution Lab, Department of Biology, Lund University, Sölvegatan 37, SE-223 62, Lund, Sweden;Department of Population Ecology, Institute of Ecology, Friedrich Schiller University Jena, Dornburger Strasse 159, D-07743, Jena, Germany;Institute of Vertebrate Biology of the Czech Academy of Sciences, Kvetna 8, 60365, Brno, Czech Republic;Present address: Max Planck Institute for the Science of Human History, Kahlaische Strasse 10, D-07745, Jena, Germany;LECA – Laboratoire d’Écologie Alpine, UMR CNRS 5553, Université Savoie Mont Blanc, F-73376, Le Bourget-du-Lac, France;Laboratory for Conservation Biology, Department of Ecology and Evolution, University of Lausanne, Biophore Building, CH-1015, Lausanne, Switzerland;MIVEGEC UMR 5290 CNRS-IRD University of Montpellier, Centre IRD, F-34394, Montpellier, France;

关键词: Birds;    Birth-death evolution;    Concerted evolution;    Gene duplication;    Gene conversion;    Major histocompatibility complex;    Recombination;   

DOI  :  10.1186/s12864-017-3839-7

 received in 2016-08-26, accepted in 2017-06-01,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundGene duplication has led to a most remarkable adaptation involved in vertebrates’ host-pathogen arms-race, the major histocompatibility complex (MHC). However, MHC duplication history is as yet poorly understood in non-mammalian vertebrates, including birds.ResultsHere, we provide evidence for the evolution of two ancient avian MHC class IIB (MHCIIB) lineages by a duplication event prior to the radiation of all extant birds >100 million years ago, and document the role of concerted evolution in eroding the footprints of the avian MHCIIB duplication history.ConclusionsOur results suggest that eroded footprints of gene duplication histories may mimic birth-death evolution and that in the avian MHC the presence of the two lineages may have been masked by elevated rates of concerted evolution in several taxa. Through the presence of a range of intermediate evolutionary stages along the homogenizing process of concerted evolution, the avian MHCIIB provides a remarkable illustration of the erosion of multigene family duplication history.

【 授权许可】

CC BY   
© The Author(s). 2017