Elevation of soluble major histocompatibility complex class I related chain A protein in malignant and infectious diseases in Chinese patients

BMC Immunology

Research Article

Leping Zeng¹  Xiao-Xin Yan¹  Ju-Fang Huang¹  Ping Yu²  Zhi Huo³  Xiaoping Wu³  Guanmin Jiang³  Yanwen Li³  Renxian Cao³  Qiuqui Zhang³  Yan Jiang³  Xiaoxin Jiang⁴ 

[1] Department of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, 410013, Changsha, Hunan, China;Department of Immunology, Xiangya School of Medicine, Central South University, 410078, Changsha, Hunan, China;The First Affiliated Hospital, Nanhua University, 421001, Hengyang, China;The First Affiliated Hospital, Nanhua University, 421001, Hengyang, China;Department of Immunology, Xiangya School of Medicine, Central South University, 410078, Changsha, Hunan, China;Department of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, 410013, Changsha, Hunan, China;

关键词: MHC;    sMICA/B;    NKG2D;    Cancer diagnosis;    Serum;   

DOI  :  10.1186/1471-2172-13-62

 received in 2012-08-09, accepted in 2012-11-23,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundElevation of soluble major histocompatibility complex class I chain-related gene A (sMICA) products in serum has been linked to tissue/organ transplantation, autoimmune diseases and some malignant disorders. Cells infected by microbiological pathogens may release sMICA, whereas less is known whether and to what extent serum sMICA levels may change in infectious diseases.MethodsThe present study determined serum sMICA levels by enzyme-linked immunosorbent assay (ELISA) in a southern China population, including patients (n = 1041) suffering from several types of malignant and infectious diseases and healthy controls (n = 141).ResultsRelative to controls, serum sMICA elevation was significant in patients of hepatic cancer, and was approaching statistical significance in patients with lung, gastric and nasopharyngeal cancers. sMICA elevation was also associated with some bacterial (Enterobacteriaceae, Mycobacterium tuberculosis, non-fermenting Gram-negative bacteria and Gram-positive cocci), viral (hepatitis B and C) and the Microspironema pallidum infections.ConclusionSerum sMICA levels may be informative for the diagnosis of some malignant and infectious diseases. The results also indicate that microbiological infections should be considered as a potential confounding clinical condition causing serum sMICA elevation while using this test to evaluate the status of other disorders, such as cancers, host-graft response and autoimmune diseases.

【 授权许可】

Unknown   
© Jiang et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.