Elevation of soluble major histocompatibility complex class I related chain A protein in malignant and infectious diseases in Chinese patients

BMC Immunology

Renxian Cao²  Ping Yu³  Xiao-Xin Yan¹  Leping Zeng¹  Guanmin Jiang²  Yanwen Li²  Xiaoping Wu²  Yan Jiang²  Qiuqui Zhang²  Zhi Huo²  Ju-Fang Huang¹  Xiaoxin Jiang¹ 

[1] Department of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, 410013, China;The First Affiliated Hospital, Nanhua University, Hengyang, 421001, China;Department of Immunology, Xiangya School of Medicine, Central South University, Changsha, Hunan, 410078, China

关键词: Serum;    Cancer diagnosis;    NKG2D;    sMICA/B;    MHC;   

Others  :  1077865
DOI  :  10.1186/1471-2172-13-62

 received in 2012-08-09, accepted in 2012-11-23,  发布年份 2012

【 摘 要 】

Background

Elevation of soluble major histocompatibility complex class I chain-related gene A (sMICA) products in serum has been linked to tissue/organ transplantation, autoimmune diseases and some malignant disorders. Cells infected by microbiological pathogens may release sMICA, whereas less is known whether and to what extent serum sMICA levels may change in infectious diseases.

Methods

The present study determined serum sMICA levels by enzyme-linked immunosorbent assay (ELISA) in a southern China population, including patients (n = 1041) suffering from several types of malignant and infectious diseases and healthy controls (n = 141).

Results

Relative to controls, serum sMICA elevation was significant in patients of hepatic cancer, and was approaching statistical significance in patients with lung, gastric and nasopharyngeal cancers. sMICA elevation was also associated with some bacterial (Enterobacteriaceae, Mycobacterium tuberculosis, non-fermenting Gram-negative bacteria and Gram-positive cocci), viral (hepatitis B and C) and the Microspironema pallidum infections.

Conclusion

Serum sMICA levels may be informative for the diagnosis of some malignant and infectious diseases. The results also indicate that microbiological infections should be considered as a potential confounding clinical condition causing serum sMICA elevation while using this test to evaluate the status of other disorders, such as cancers, host-graft response and autoimmune diseases.

【 授权许可】

   
2012 Jiang et al.; licensee BioMed Central Ltd.

【 图 表 】

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