Adipo/cytokines in atherosclerotic secretomes: increased visfatin levels in unstable carotid plaque

BMC Cardiovascular Disorders

Research Article

Carmen Aguilar¹  Gemma Aragonès¹  Esther Guiu-Jurado¹  Alba Berlanga¹  Marta Curriu¹  Cristóbal Richart²  Teresa Auguet²  Salomé Martinez³  Vicente Martín-Paredero⁴  Esteban Hernández⁴  Ajla Alibalic⁵  María-Luisa Camara⁶  Xavier Ruyra⁶ 

[1] Grup de Recerca GEMMAIR - Medicina Aplicada. Departament de Medicina i Cirurgia, Universitat Rovira i Virgili (URV), Institut Investigació Sanitària Pere Virgili (IISPV), 43007, Tarragona, Spain;Grup de Recerca GEMMAIR - Medicina Aplicada. Departament de Medicina i Cirurgia, Universitat Rovira i Virgili (URV), Institut Investigació Sanitària Pere Virgili (IISPV), 43007, Tarragona, Spain;Servei Medicina Interna, Hospital Universitari Joan XXIII, 43007, Tarragona, Spain;Servei Anatomia Patològica, Hospital Universitari Joan XXIII, 43007, Tarragona, Spain;Servei Angiologia i Cirurgia Vascular, Hospital Universitari Joan XXIII, 43007, Tarragona, Spain;Servei Medicina Interna, Hospital Universitari Joan XXIII, 43007, Tarragona, Spain;Servei de Cirurgia Cardíaca, Hospital Germans Trias i Pujol, 08916, Badalona, Spain;

关键词: Atheroma plaque;    Secretome;    Visfatin;    Atherosclerosis;    Adipo/cytokines;   

DOI  :  10.1186/s12872-016-0320-5

 received in 2015-12-22, accepted in 2016-06-10,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundNovel pro-inflammatory and anti-inflammatory derivatives from adipose tissue, known as adipokines, act as metabolic factors. The aim of this study was to analyse the secreted expression of different adipo/cytokines in secretomes of unstable carotid atherosclerotic plaque versus non-atherosclerotic mammary artery.MethodsWe evaluated the secretion levels of adiponectin, visfatin, lipocalin-2, resistin, IL-6 and TNFR2 by ELISA in human secretomes from cultured unstable carotid atherosclerotic plaque (n = 18) and non-atherosclerotic mammary artery (n = 13). We also measured visfatin serum levels in patients suffering from atherosclerosis and in a serum cohort of healthy subjects (n = 16).ResultsWe found that visfatin levels were significantly increased in unstable carotid atherosclerotic plaque secretome than in non-atherosclerotic mammary artery secretome. No differences were found with regard the other adipo/cytokines studied. Regarding visfatin circulating levels, there were no differences between unstable carotid atherosclerotic plaque and non-atherosclerotic mammary artery group. However, these visfatin levels were increased in comparison to serum cohort of healthy subjects.ConclusionsOf all the adipo/cytokines analysed, only visfatin showed increased levels in secretomes of unstable carotid atherosclerotic plaque. Additional human studies are needed to clarify the possible role of visfatin as prognostic factor of unstable carotid atherosclerotic plaque.

【 授权许可】

CC BY   
© The Author(s). 2016