Association between serum visfatin levels and atherosclerotic plaque in patients with type 2 diabetes

Diabetology & Metabolic Syndrome

Sheng Xia¹  Jin Lu¹  Qin Huang¹  Ren-Hui Wan¹  Long-Yi Zheng¹  Xia Xu² 

[1] Department of Endocrinology, Changhai Hospital, Second Military Medical University;Department of Rheumatology and Immunology, Changhai Hospital, Second Military Medical University;

关键词: Visfatin;    Type 2 diabetes mellitus;    Atherosclerosis;    Carotid plaques;   

DOI  :  10.1186/s13098-019-0455-5

来源: DOAJ

【 摘 要 】

Abstract Background Visfatin is a multifaceted protein that plays an important role in regulating a variety of physiological and pathological processes, including obesity, diabetes and cardiovascular disease. However, circulating visfatin levels in atherosclerosis plaque progression in patients with type 2 diabetes, or its association with the vascular territory affected remain unclear. Methods We evaluated the relationship between visfatin levels and carotid or femoral artery atherosclerosis in Chinese patients with type 2 diabetes. Serum levels of visfatin were measured by enzyme-linked immunosorbent assay (ELISA) in 97 inpatients with type 2 diabetes. Carotid and/or femoral atherosclerotic plaques were detected by B-mode ultrasound. Results Serum visfatin levels were elevated in the group with atherosclerotic plaques compared to the control group without plaques [0.68 (0.46–1.58) versus 0.45 (0.23–0.76) ng/mL, respectively, P = 0.0002]. Patients with carotid plaques showed higher visfatin levels than those with or without femoral plaques. Pearson’s correlation analysis showed that serum visfatin levels were positively correlated with waist circumference (r = 0.226, P = 0.029), waist-hip ratio (r = 0.221, P = 0.032), TG (r = 0.222, P = 0.030) and number of plaques (r = 0.275, P = 0.009). Logistic regression analysis showed that a higher serum visfatin level was an independent predictor for the presence of atherosclerotic plaques. Conclusions In conclusion, among patients with T2DM, serum visfatin levels were elevated in those with atherosclerotic plaques, especially in patients with carotid atherosclerotic plaques. Serum visfatin may serve as a predictor of atherosclerotic plaques in patients with T2DM.

【 授权许可】

Unknown