The protective effects of Resveratrol against radiation-induced intestinal injury

BMC Complementary and Alternative Medicine

Research Article

Yiling Yang¹  Hui Wang²  Hao Yan²  Heng Zhang²  Huaqing Wang²  Xiaoliang Zhou³  Junling Zhang⁴ 

[1] Department of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and Hospital, Huanhuxi Road, Hexi District, Tianjin, China;Department of Oncology, Institute of Integrative Oncology, Tianjin Union Medical Center, 190, Jieyuan Road, Hongqiao District, 300121, Tianjin, China;Department of Pharmaceutical, Institute of Radiation Medicine, Chinese Academy of Medical Sciences, 238 Baidi Road, Nankai District, Tianjin, China;Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Chinese Academy of Medical Sciences, Tianjin, China;

关键词: Ionizing radiation protection;    Small intestine;    Mice;    Radiation damage;   

DOI  :  10.1186/s12906-017-1915-9

 received in 2017-02-09, accepted in 2017-08-08,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundIntestinal injury is a potential cause of death after high-dose radiation exposure. The aim of the present study was to investigate the protective effects of resveratrol against radiation-induced small intestine injury.MethodsC57BL/6 N mice were irradiated and treated with resveratrol and/or Ex527 (a potent Sirt1 inhibitor), and subsequent examining intestinal morphological changes, and crypt cell apoptosis. Then, the expression and enzyme activity of SOD2 in the small intestine were examined. Furthermore, Sirt1 and acetylated p53 expression was analysed.ResultsCompared to the vehicle control, treatment with resveratrol improved intestinal morphology, decreased apoptosis of crypt cells, maintained cell regeneration, and ameliorated SOD2 expression and activity. Resveratrol also regulated Sirt1 and acetylated p53 expression perturbed by irradiation in the small intestine. The protective effect of resveratrol against ionizing radiation induced small intestine injury was significantly inhibited by Ex527.ConclusionOur results suggest that resveratrol decreases the effects of radiation on intestinal injury at least partly via activation of Sirt1.

【 授权许可】

CC BY   
© The Author(s). 2017