Behavior of copper oxide nanoparticles in gastrointestinal juice

3rd International Conference on Energy Equipment Science and Engineering

Dang, Yonghui^1 ; Li, Yue^1 ; Ji, Yongbo^1 ; Xu, Lina^1 ; Tan, Huiwen^1 ; Xu, Dongfang^1 ; Wei, Yongpeng^1

Key Laboratory of Marine Environment and Ecology, Ministry of Education and College of Environmental Science and Engineering, Ocean University of China, Qingdao

266100, China^1

关键词: Copper oxide nanoparticles;    CuO nanoparticles;    Gastric juice;    Small intestine;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/128/1/012178/pdf
DOI  :  10.1088/1755-1315/128/1/012178

来源: IOP

【 摘 要 】

In this work, we investigated the behavior of CuO nanoparticles (NPs) in simulated gastrointestinal juices. It was found that CuO NPs agglomerated significantly in the gastric and small intestine phases, with a higher agglomeration in the small intestine than that in the gastric phase, which was consistent with the results on zeta potentials. Dissolution experiment showed that CuO NPs released more Cu2+in the gastric phase (pH = 2.5) than that in the small intestine phase (pH = 7). This was due to much lower pH in gastric juice, leading to higher dissolution of CuO NPs.