Cell-free and intracellular nucleic acids: new non-invasive biomarkers to explore male infertility

Basic and Clinical Andrology

Review Article

Amaël Petiton¹  Solenne Baillet¹  Antoine Torre¹  Anne Boissière²  Alice Ferrières-Hoa³  Samir Hamamah³  Tiffany Mullet³  Anna Gala³ 

[1] Département de biologie de la reproduction, Hôpital Arnaud de Villeneuve, CHRU Montpellier, 371, avenue du Doyen-Gaston-Giraud, 34295, Montpellier, France;Unité INSERM U1203, Hôpital Saint Eloi, CHRU Montpellier, 80, avenue Fliche, 34295, Montpellier, France;Unité INSERM U1203, Hôpital Saint Eloi, CHRU Montpellier, 80, avenue Fliche, 34295, Montpellier, France;Département de biologie de la reproduction, Hôpital Arnaud de Villeneuve, CHRU Montpellier, 371, avenue du Doyen-Gaston-Giraud, 34295, Montpellier, France;

关键词: cf-DNA;    cf-mRNA;    miRNA;    piRNA;    Male infertility;    Seminal plasma;    biomarkers;    cf-DNA;    cf-mRNA;    miRNA;    piRNA;    Infertilité masculine;    Plasma séminal;    Biomarqueurs;   

DOI  :  10.1186/s12610-017-0052-0

 received in 2016-12-06, accepted in 2017-03-09,  发布年份 2017

来源: Springer

【 摘 要 】

Male infertility is a devastating problem that affects many couples worldwide. However, the molecular mechanisms and causes of idiopathic male infertility remain unclear. Circulating cell-free nucleic acids have an important role in human physiology and emerging evidence suggests that they play a role in male infertility. This review summarizes recent results on cell-free and intracellular nucleic acids in male infertility and discusses their potential use as biomarkers of male infertility in the clinical practice.

【 授权许可】

CC BY   
© The Author(s). 2017