Overexpression of p53R2 is associated with poor prognosis in lung sarcomatoid carcinoma

BMC Cancer

Research Article

Jiewei Chen¹  Keming Chen¹  Jun Liu¹  Xinke Zhang¹  Yongbo Xiao¹  Xiaoyan Cai² 

[1] Department of Pathology, Sun Yat-Sen University Cancer Center, 510060, Guangzhou, China;Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China;Department of Pathology, Taishan People’s Hospital, 529200, Taishan, Guangdong, China;

关键词: Lung sarcomatoid carcinoma;    p53R2;    Immunohistochemistry;    Prognosis;   

DOI  :  10.1186/s12885-017-3811-6

 received in 2017-07-25, accepted in 2017-11-21,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThis study aimmed to evaluate the expression of p53-inducible RR small subunit 2 homologue (p53R2) in Lung sarcomatoid carcinoma (LSC) and its association with clinicopathological parameters and prognosis.MethodsIn this study, clinicopathological factors and prognostic significance of the expression of p53R2 was investigated by immunohistochemistry (IHC) in 100 cases of LSC.ResultsThe results showed that the expression of p53R2 was significantly correlated with clinical stage (P<0.05). But there was no statistically correlation with gender, age, smoking, tumor size, pT stage, pN stage, pM stage, therapy and relapse. Kaplan-Meier analysis revealed that the expression of p53R2, clinical stage, pT stage, pN stage, pM stage and tumor size were closely related to patients’ survival, and the analysis also revealed that patients with low expression of p53R2 had a longer overall survival than that with high expression (Mean overall survival: 84.8 months vs. 34.7 months, P<0.05). Further multivariate analysis indicated that the expression of p53R2 was identified as an independent prognostic factor in the prediction of the overall survival for patients with LSC (HR = 3.217, P<0.05).ConclusionsThe expression of p53R2 was inversely associated with the proliferation and progression of LSC, and the results indicated that the high expression of p53R2 was an independent factor for unfavorable prognosis of patients with LSC.

【 授权许可】

CC BY   
© The Author(s). 2017