p53R2 as a novel prognostic biomarker in nasopharyngeal carcinoma

BMC Cancer

Research Article

Xuan Zou¹  Shuman Li²  Jiewei Chen³  Mingshu Zhu³  Xinke Zhang³  Dan Xie³  Muyan Cai³  Yongbo Xiao³ 

[1] Department of Pathology, The Sixth Affiliated Hospital, Sun Yat-sen University, 510655, Guangzhou, China;Sun Yat-sen University Cancer Center ; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, China;Sun Yat-sen University Cancer Center ; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, China;Department of Pathology, Sun Yat-sen University Cancer Center, No. 651, Dongfeng East Road, 510060, Guangzhou, China;

关键词: Nasopharyngeal carcinoma;    p53R2;    Immunohistochemistry;    Prognosis;   

DOI  :  10.1186/s12885-017-3858-4

 received in 2017-07-30, accepted in 2017-11-29,  发布年份 2017

来源: Springer

【 摘 要 】

Backgroundp53R2 is a target of p53 gene, which is essential for DNA repair, mitochondrial DNA synthesis, protection against oxidative stress, chromosomal instability, chronic inflammation and tumorigenesis. This study is aimed to investigate the expression of ribonucleotide reductase (RR) subunit p53R2 in nasopharyngeal carcinoma and its significance in the prognosis.MethodsThe expression levels of p53R2 in 201 patients with NPC were examined by immunohistochemical assay. The correlations of p53R2 expression and clinicopathological features of nasopharyngeal carcinoma patient were analysed by chi-square test. The Kaplan-Meier survival analysis and Cox multivariate regression model were used to analyze the prognostic significance of the patients with NPC.ResultsImmunohistochemical results showed that p53R2 was positively expressed in 92.5% (186/201) of nasopharyngeal carcinoma and the high expression rate was 38.3% (77/201). Further analysis observed that the negative correlation between expression of p53R2 and pT status had statistical significance (P < 0.05). Kaplan-Meier survival analysis found that the mean survival time of patients with high expression of p53R2 was 143.32 months, while the patients with low expression level of p53R2 was 121.63 months (P < 0.05). Cox regression analysis suggested that p53R2 protein expression could be used as an independent prognostic factor for nasopharyngeal carcinoma (P < 0.05).ConclusionsThis study drew a conclusion that p53R2 could be used as a prognostic biomarker indicative of the favorable outcome for patients with nasopharyngeal carcinoma.

【 授权许可】

CC BY   
© The Author(s). 2017