Study protocol for the Maule Cohort (MAUCO) of chronic diseases, Chile 2014–2024

BMC Public Health

Study Protocol

Marcelo J. Kogan¹  Alvaro Passi²  Alejandro H. Corvalán²  Sandra Cortés²  Rolando de la Cruz²  Claudia Bambs²  Francisco Cruz²  Catterina Ferreccio²  Juan Carlos Roa²  Juan Francisco Miquel²  Claudia Foerster²  Pablo Toro²  Yerko Covacevich²  Alejandra Vives²  Pablo F. Castro²  Johanna Acevedo²  Andrea Huidobro³  Andrew F. Quest⁴  Sergio Lavandero⁵  Jill Koshiol⁶  Raúl Silva⁷  Mauricio Olivares⁸ 

[1] Advanced Center for Chronic Diseases (ACCDiS), Facultad Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile;Advanced Center for Chronic Diseases (ACCDiS), Facultad Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile;Advanced Center for Chronic Diseases (ACCDiS), Facultad Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile;Facultad Medicina, Universidad Católica del Maule, Talca, Chile;Advanced Center for Chronic Diseases (ACCDiS), Facultad Medicina, Universidad de Chile, Santiago, Chile;Advanced Center for Chronic Diseases (ACCDiS), Facultad Medicina, Universidad de Chile, Santiago, Chile;Advanced Center for Chronic Diseases (ACCDiS), Facultad Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile;Cardiology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA;Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch, National Cancer Institute, Bethesda, MD, USA;Facultad Medicina, Universidad Católica del Maule, Talca, Chile;Hospital Santa Rosa de Molina, Curicó, Chile;

关键词: Prospective studies;    Cohort studies;    Population surveillance;    Chronic disease/epidemiology;    Agricultural workers diseases;    Cardiovascular diseases;    Neoplasms/Epidemiology;   

DOI  :  10.1186/s12889-015-2454-2

 received in 2015-09-20, accepted in 2015-10-26,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundMaule Cohort (MAUCO), a Chilean cohort study, seeks to analyze the natural history of chronic diseases in the agricultural county of Molina (40,000 inhabitants) in the Maule Region, Chile. Molina´s population is of particular interest because in the last few decades it changed from being undernourished to suffering excess caloric intake, and it currently has the highest national rates of cardiovascular diseases, stomach cancer and gallbladder cancer. Between 2009 and 2011 Molina´s poverty rate dropped from 24.1 % to 13.5 % (national average 20.4 %); in this period the county went from insufficient to almost complete basic sanitation. Despite these advances, chemical pollutants in the food and air are increasing. Thus, in Molina risk factors typical of both under-developed and developed countries coexist, generating a unique profile associated with inflammation, oxidative stress and chronic diseases.Methods/DesignMAUCO is the core project of the recently established Advanced Center for Chronic Diseases (ACCDiS), Universidad de Chile & Pontificia Universidad Católica de Chile. In this study, we are enrolling and following 10,000 adults aged 38 to 74 years over 10 years. All eligible Molina residents will be enrolled. Participants were identified through a household census. Consenting individuals answer an epidemiological survey exploring risk factors (psycho-social, pesticides, diet, alcohol, and physical activity), medical history and physical and cognitive conditions; provide fasting blood, urine, and saliva samples; receive an electrocardiogram, abdominal ultrasound and bio-impedance test; and take a hand-grip strength test. These subjects will be re-interviewed after 2, 5 and 7 years. Active surveillance of health events is in place throughout the regional healthcare system. The MAUCO Bio-Bank will store 30 to 50 aliquots per subject using an NIH/NCI biorepository system for secure and anonymous linkage of samples with data.DiscussionMAUCO´s results will help design public health interventions tailored to agricultural populations in Latin America.

【 授权许可】

CC BY   
© Ferreccio et al. 2016