Using principal component analysis to develop a single-parameter screening tool for metabolic syndrome

BMC Public Health

Research Article

Ching-Ho Yen¹  Mei-Yen Chen²  Chia-Hao Chang³ 

[1] Department of Industrial Engineering & Management Information, Huafan University, 22301, Taipei, Taiwan;Department of Nursing, Chang Gung Institute of Technology, 33303, Taoyuan, Taiwan;Department of Nursing, Chang Gung Institute of Technology, Chiayi Campus, 61363, Chiayi, Taiwan;Department of Respiratory Care, Chang Gung Institute of Technology, Chiayi Campus, 61363, Chiayi, Taiwan;

关键词: Body Mass Index;    Metabolic Syndrome;    Waist Circumference;    Receiver Operating Characteristic Curve;    Fast Plasma Glucose;   

DOI  :  10.1186/1471-2458-10-708

 received in 2010-04-15, accepted in 2010-11-18,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundMetabolic syndrome (MS) is an important current public health problem faced worldwide. To prevent an "epidemic" of this syndrome, it is important to develop an easy single-parameter screening technique (such as waist circumference (WC) determination recommended by the International Diabetes Federation). Previous studies proved that age is a chief factor corresponding to central obesity. We intended to present a new index based on the linear combination of body mass index, and age, which could enhance the area under the receiver operating characteristic curves (AUCs) for assessing the risk of MS.MethodsThe labour law of the Association of Labor Standard Law, Taiwan, states that employers and employees are respectively obligated to offer and receive routine health examination periodically. Secondary data analysis and subject's biomarkers among five high-tech factories were used in this study between 2007 and 2008 in northern Taiwan. The subjects included 4712 males and 4196 females. The first principal component score (FPCS) and equal-weighted average (EWA) were determined by statistical analysis.ResultsMost of the metabolic and clinical characteristics were significantly higher in males than in females, except high-density lipoprotein cholesterol level. The older group (>45 years) had significantly lower values for height and high-density lipoprotein cholesterol level than the younger group. The AUCs of FPCS and EWA were significantly larger than those of WC and waist-to-height ratio. The low specificities of EWA and FPCS were compensated for by their substantially high sensitivities. FPCS ≥ 0.914 (15.4%) and EWA ≥ 8.8 (6.3%) were found to be the most prevalent cut off points in males and females, respectively.ConclusionsThe Bureau of Health Promotion, Department of Health, Taiwan, had recommended the use of WC ≥ 90 cm for males and ≥ 80 cm for females as singular criteria for the determination of central obesity instead of multiple parameters. The present investigation suggests that FPCS or EWA is a good predictor of MS among the Taiwanese. However, the use of FPCS is not computationally feasible in practice. Therefore, we suggest that EWA be used in clinical practice as a simple parameter for the identification of those at risk of MS.

【 授权许可】

Unknown   
© Chang et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.