Relationships between lipid profiles and metabolic syndrome, insulin resistance and serum high molecular adiponectin in Japanese community-dwelling adults

Lipids in Health and Disease

Research

Masanori Abe¹  Shuzo Takayama¹  Tomo Kusunoki²  Ryuichi Kawamoto²  Yasuharu Tabara³  Katsuhiko Kohara³  Tetsuro Miki³  Tateaki Katoh⁴  Nobuyuki Ohtsuka⁴ 

[1] Department of Community Medicine, Ehime University Graduate School of Medicine, 791-0295, Ehime, Japan;Department of Community Medicine, Ehime University Graduate School of Medicine, 791-0295, Ehime, Japan;Department of Internal Medicine, Seiyo Municipal Nomura Hospital, 797-1212, Ehime, Japan;Department of Geriatric Medicine, Ehime University Graduate School of Medicine, 791-0295, Ehime, Japan;Department of Internal Medicine, Seiyo Municipal Nomura Hospital, 797-1212, Ehime, Japan;

关键词: Insulin Resistance;    Metabolic Syndrome;    Lipid Profile;    Receiver Operating Characteristic Curve;    Fast Blood Glucose;   

DOI  :  10.1186/1476-511X-10-79

 received in 2011-03-13, accepted in 2011-05-17,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundThere are few studies to demonstrate the associations between newly addressed lipid profiles and metabolic syndrome (MetS)-associated variables.MethodsStudy participants without medications for hypertension, diabetes, or dyslipidemia {614 men aged 58 ± 14 (mean ± standard deviation; range, 20-89) years and 779 women aged 60 ± 12 (range, 21-88) years} were randomly recruited from a single community at the time of their annual health examination. The association between lipid profiles (total cholesterol (T-C), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), non-HDL-C, T-C/HDL-C, TG/HDL-C, LDL-C/HDL-C ratio and MetS, Insulin resistance by homeostasis model assessment of insulin resistance (HOMA-IR), and serum HMW adiponectin were analyzed.ResultsIn multiple linear regression analysis, TG/HDL-C and T-C/HDL-C ratios as well as TG showed significantly strong associations with all three MetS-associated variables in both men and women. In men, the ROC curve analyses showed that the best marker for these variables was TG/HDL-C ratio, with the AUC for presence of MetS (AUC, 0.82; 95% CI, 0.77-0.87), HOMA-IR (AUC, 0.75; 95% CI, 0.70-0.80), and serum HMW adiponectin (AUC, 0.67; 95% CI, 0.63-0.71), respectively. The T-C/HDL-C ratio, TG, HDL-C, LDL-C/HDL-C ratio, and non-HDL-C also discriminated these markers; however all their AUC estimates were lower than TG/HDL-C ratio. These results were similar in women.ConclusionIn Japanese community-dwelling adults, lipid ratios of TG/HDL-C, T-C/HDL-C, LDL-C/HDL-C as well as TG and HDL-C were consistently associated with MetS, insulin resistance and serum HMW adiponectin. Lipid ratios may be used as reliable markers.

【 授权许可】

CC BY   
© Kawamoto et al; licensee BioMed Central Ltd. 2011