Lipids in Health and Disease | |
Relationships between lipid profiles and metabolic syndrome, insulin resistance and serum high molecular adiponectin in Japanese community-dwelling adults | |
Research | |
Masanori Abe1  Shuzo Takayama1  Tomo Kusunoki2  Ryuichi Kawamoto2  Yasuharu Tabara3  Katsuhiko Kohara3  Tetsuro Miki3  Tateaki Katoh4  Nobuyuki Ohtsuka4  | |
[1] Department of Community Medicine, Ehime University Graduate School of Medicine, 791-0295, Ehime, Japan;Department of Community Medicine, Ehime University Graduate School of Medicine, 791-0295, Ehime, Japan;Department of Internal Medicine, Seiyo Municipal Nomura Hospital, 797-1212, Ehime, Japan;Department of Geriatric Medicine, Ehime University Graduate School of Medicine, 791-0295, Ehime, Japan;Department of Internal Medicine, Seiyo Municipal Nomura Hospital, 797-1212, Ehime, Japan; | |
关键词: Insulin Resistance; Metabolic Syndrome; Lipid Profile; Receiver Operating Characteristic Curve; Fast Blood Glucose; | |
DOI : 10.1186/1476-511X-10-79 | |
received in 2011-03-13, accepted in 2011-05-17, 发布年份 2011 | |
来源: Springer | |
【 摘 要 】
BackgroundThere are few studies to demonstrate the associations between newly addressed lipid profiles and metabolic syndrome (MetS)-associated variables.MethodsStudy participants without medications for hypertension, diabetes, or dyslipidemia {614 men aged 58 ± 14 (mean ± standard deviation; range, 20-89) years and 779 women aged 60 ± 12 (range, 21-88) years} were randomly recruited from a single community at the time of their annual health examination. The association between lipid profiles (total cholesterol (T-C), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), non-HDL-C, T-C/HDL-C, TG/HDL-C, LDL-C/HDL-C ratio and MetS, Insulin resistance by homeostasis model assessment of insulin resistance (HOMA-IR), and serum HMW adiponectin were analyzed.ResultsIn multiple linear regression analysis, TG/HDL-C and T-C/HDL-C ratios as well as TG showed significantly strong associations with all three MetS-associated variables in both men and women. In men, the ROC curve analyses showed that the best marker for these variables was TG/HDL-C ratio, with the AUC for presence of MetS (AUC, 0.82; 95% CI, 0.77-0.87), HOMA-IR (AUC, 0.75; 95% CI, 0.70-0.80), and serum HMW adiponectin (AUC, 0.67; 95% CI, 0.63-0.71), respectively. The T-C/HDL-C ratio, TG, HDL-C, LDL-C/HDL-C ratio, and non-HDL-C also discriminated these markers; however all their AUC estimates were lower than TG/HDL-C ratio. These results were similar in women.ConclusionIn Japanese community-dwelling adults, lipid ratios of TG/HDL-C, T-C/HDL-C, LDL-C/HDL-C as well as TG and HDL-C were consistently associated with MetS, insulin resistance and serum HMW adiponectin. Lipid ratios may be used as reliable markers.
【 授权许可】
CC BY
© Kawamoto et al; licensee BioMed Central Ltd. 2011
【 预 览 】
Files | Size | Format | View |
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RO202311103286147ZK.pdf | 363KB | download |
【 参考文献 】
- [1]
- [2]
- [3]
- [4]
- [5]
- [6]
- [7]
- [8]
- [9]
- [10]
- [11]
- [12]
- [13]
- [14]
- [15]
- [16]
- [17]
- [18]
- [19]
- [20]
- [21]
- [22]
- [23]
- [24]
- [25]
- [26]
- [27]
- [28]
- [29]
- [30]
- [31]
- [32]
- [33]
- [34]