Anticonvulsant and neuroprotective effects of Pimpinella anisum in rat brain

BMC Complementary and Alternative Medicine

Research Article

Gholam Reza Hassanzadeh¹  Mohamad Bayat¹  Hadi Kazemi²  Mahmoud Hosseini³  Diana Mangeng⁴  Hassan Alavi⁵  Maryam Jafarian⁶  Ali Gorji⁷  Fariba Karimzadeh⁸ 

[1] Department of Anatomy, Tehran University of Medical Sciences, Tehran, Iran;Department of Pediatric, Shahed University, Tehran, Iran;Department of Physiology, Mashhad University of Medical Sciences, Mashhad, Iran;Institut für Physiologie I, Westfalische Wilhelms-University Münster, Münster, Germany;Mashhad Neuroscience Center, University of Medical Sciences, Mashhad, Iran;Shefa Neuroscience Center, Tehran, Iran;Shefa Neuroscience Center, Tehran, Iran;Institut für Physiologie I, Westfalische Wilhelms-University Münster, Münster, Germany;Razavi Neuroscience Center, Mashhad, Iran;Shefa Neuroscience Center, Tehran, Iran;Mashhad Neuroscience Center, University of Medical Sciences, Mashhad, Iran;

关键词: Cephalic pain;    Stroke;    Brain ischemia;    Medical plants;    Traditional therapy;   

DOI  :  10.1186/1472-6882-12-76

 received in 2012-01-10, accepted in 2012-06-18,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundEssential oil of Pimpinella anisum L. Apiaceae (anise oil) has been widely used in traditional Persian medicine to treat a variety of diseases, including some neurological disorders. This study was aimed to test the possible anti-seizure and anti-hypoxia effects of anise oil.MethodsThe effects of different concentrations of anise oil were tested on seizure attacks induced by pentylenetetrazol (PTZ) injection and neuronal hypoxia induced by oxygen withdrawal as well as on production of dark neurons and induction of long-term potentiation (LTP) in in vivo and in vitro experimental models of rat brain.ResultsAnise oil significantly prolonged the latency of seizure attacks and reduced the amplitude and duration of epileptiform burst discharges induced by injection of intraperitoneal PTZ. In addition, anise oil significantly inhibited production of dark neurons in different regions of the brain in epileptic rats. Anise oil also significantly enhanced the duration of the appearance of anoxic terminal negativity induced by oxygen withdrawal and inhibited induction of LTP in hippocampal slices.ConclusionsOur data indicate the anticonvulsant and neuroprotective effects of anise oil, likely via inhibition of synaptic plasticity. Further evaluation of anise oil to use in the treatment of neurological disorders is suggested.

【 授权许可】

Unknown   
© Karimzadeh et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.