Anticonvulsant and neuroprotective effects of Pimpinella anisum in rat brain

BMC Complementary and Alternative Medicine

Ali Gorji⁵  Hadi Kazemi²  Maryam Jafarian¹  Mohamad Bayat⁴  Gholam Reza Hassanzadeh⁴  Hassan Alavi⁶  Diana Mangeng³  Mahmoud Hosseini⁷  Fariba Karimzadeh⁶ 

[1] Shefa Neuroscience Center, Tehran, Iran;Department of Pediatric, Shahed University, Tehran, Iran;Institut für Physiologie I, Westfalische Wilhelms-University Münster, Münster, Germany;Department of Anatomy, Tehran University of Medical Sciences, Tehran, Iran;Razavi Neuroscience Center, Mashhad, Iran;Mashhad Neuroscience Center, University of Medical Sciences, Mashhad, Iran;Department of Physiology, Mashhad University of Medical Sciences, Mashhad, Iran

关键词: Traditional therapy;    Medical plants;    Brain ischemia;    Stroke;    Cephalic pain;   

Others  :  1232139
DOI  :  10.1186/1472-6882-12-76

 received in 2012-01-10, accepted in 2012-06-18,  发布年份 2012

【 摘 要 】

Background

Essential oil of Pimpinella anisum L. Apiaceae (anise oil) has been widely used in traditional Persian medicine to treat a variety of diseases, including some neurological disorders. This study was aimed to test the possible anti-seizure and anti-hypoxia effects of anise oil.

Methods

The effects of different concentrations of anise oil were tested on seizure attacks induced by pentylenetetrazol (PTZ) injection and neuronal hypoxia induced by oxygen withdrawal as well as on production of dark neurons and induction of long-term potentiation (LTP) in in vivo and in vitro experimental models of rat brain.

Results

Anise oil significantly prolonged the latency of seizure attacks and reduced the amplitude and duration of epileptiform burst discharges induced by injection of intraperitoneal PTZ. In addition, anise oil significantly inhibited production of dark neurons in different regions of the brain in epileptic rats. Anise oil also significantly enhanced the duration of the appearance of anoxic terminal negativity induced by oxygen withdrawal and inhibited induction of LTP in hippocampal slices.

Conclusions

Our data indicate the anticonvulsant and neuroprotective effects of anise oil, likely via inhibition of synaptic plasticity. Further evaluation of anise oil to use in the treatment of neurological disorders is suggested.

【 授权许可】

   
2012 Karimzadeh et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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