Detection of antibodies directed at M. hyorhinis p37 in the serum of men with newly diagnosed prostate cancer

BMC Cancer

Research Article

Susan K Boehlein¹  Chen-zhong Li²  Myron Chang³  Steve Goodison⁴  Noburo Sakamoto⁵  Stacy Porvasnik⁵  Cydney Urbanek⁵  Charles J Rosser⁵ 

[1] Department of Biochemistry, The University of Florida, 32610, Gainesville, Florida, USA;Department of Biomedical Engineering, Florida International University, 33174, Miami, Florida, USA;Department of Biostatistics, The University of Florida, 32610, Gainesville, Florida, USA;Department of Surgery, The University of Florida, 32209, Jacksonville, Florida, USA;Department of Urology, The University of Florida, 32610, Gainesville, Florida, USA;

关键词: Mycoplasma hyorhinis;    ELISA;    cancer;    prostate;   

DOI  :  10.1186/1471-2407-11-233

 received in 2011-02-11, accepted in 2011-06-10,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundRecent epidemiologic, genetic, and molecular studies suggest infection and inflammation initiate certain cancers, including cancers of the prostate. Over the past several years, our group has been studying how mycoplasmas could possibly initiate and propagate cancers of the prostate. Specifically, Mycoplasma hyorhinis encoded protein p37 was found to promote invasion of prostate cancer cells and cause changes in growth, morphology and gene expression of these cells to a more aggressive phenotype. Moreover, we found that chronic exposure of benign human prostate cells to M. hyorhinis resulted in significant phenotypic and karyotypic changes that ultimately resulted in the malignant transformation of the benign cells. In this study, we set out to investigate another potential link between mycoplasma and human prostate cancer.MethodsWe report the incidence of men with prostate cancer and benign prostatic hyperplasia (BPH) being seropositive for M. hyorhinis. Antibodies to M. hyorhinis were surveyed by a novel indirect enzyme-linked immunosorbent assay (ELISA) in serum samples collected from men presenting to an outpatient Urology clinic for BPH (N = 105) or prostate cancer (N = 114) from 2006-2009.ResultsA seropositive rate of 36% in men with BPH and 52% in men with prostate cancer was reported, thus leading us to speculate a possible connection between M. hyorhinis exposure with prostate cancer.ConclusionsThese results further support a potential exacerbating role for mycoplasma in the development of prostate cancer.

【 授权许可】

Unknown   
© Urbanek et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.