Interactions between oestrogen and 1α,25(OH)2-vitamin D3 signalling and their roles in spermatogenesis and spermatozoa functions

Basic and Clinical Andrology

Review Article

Fátima Regina Mena Barreto Silva¹  Hélène Bouraïma-Lelong²  Camille Gautier²  Vanessa Brouard²  Renata Goncalves³  Ana Paula Zanatta³  Christelle Delalande⁴ 

[1] Biochemistry Department, Laboratory of Hormones & Signal Transduction, UFSC, Florianópolis, Brazil;INRA, OeReCa, Normandie University, UNICAEN, 14000, Caen, France;INRA, OeReCa, Normandie University, UNICAEN, 14000, Caen, France;Biochemistry Department, Laboratory of Hormones & Signal Transduction, UFSC, Florianópolis, Brazil;INRA, OeReCa, Normandie University, UNICAEN, 14000, Caen, France;Laboratoire Œstrogènes, Reproduction, Cancer (OeReCa), EA 2608 USC INRA1377, Université de Caen Normandie, Esplanade de la Paix, CS 14032, 14032, CAEN cedex 5, France;

关键词: Oestrogen;    1α,25(OH)-vitamin D (1,25-D);    Spermatogenesis;    Spermatozoa;    Steroid receptors;    Œstrogènes;    1,25(OH)-vitamine D (1,25-D);    Spermatogenèse;    Spermatozoïde;    Récepteurs aux stéroïdes;   

DOI  :  10.1186/s12610-017-0053-z

 received in 2016-10-17, accepted in 2017-03-16,  发布年份 2017

来源: Springer

【 摘 要 】

Oestrogens and 1α,25(OH)2-vitamin D3 (1,25-D3) are steroids that can provide effects by binding to their receptors localised in the cytoplasm and in the nucleus or the plasma membrane respectively inducing genomic and non-genomic effects. As confirmed notably by invalidation of the genes, coding for their receptors as tested with mice with in vivo and in vitro treatments, oestrogens and 1,25-D3 are regulators of spermatogenesis. Moreover, some functions of ejaculated spermatozoa as viability, DNA integrity, motility, capacitation, acrosome reaction and fertilizing ability are targets for these hormones. The studies conducted on their mechanisms of action, even though not completely elicited, have allowed the demonstration of putative interactions between their signalling pathways that are worth examining more closely. The present review focuses on the elements regulated by oestrogens and 1,25-D3 in the testis and spermatozoa as well as the interactions between the signalling pathways of both hormones.

【 授权许可】

CC BY   
© The Author(s). 2017