Immunohistochemical expression of oestrogen and progesterone receptors during experimental acute and chronic murine Schistosomiasis mansoni

Revista da Sociedade Brasileira de Medicina Tropical

Fawzia Ahmed Habib²  Mayssa Mohamed Zaki¹  Amany Ahmed Abd El-aal¹  Maha Dia Eldean Safwat¹  Magda Ahmed El Domiaty¹ 

[1] ,Taibah University Faculty of Medicine Obstetrics and Gynecology Department,Saudi Arabia

关键词: Schistosoma mansoni;    Endometrium;    Hormone receptors;    Oestrogen;    Progesterone-immunohistochemistry;    Schistosoma mansoni;    Endométrio;    Receptores hormonais;    Oestrogen;    Progesterona-imuno-histoquímica;   

DOI  :  10.1590/S0037-86822010000500012

来源: SciELO

【 摘 要 】

INTRODUCTION: The responsibility of Schistosoma mansoni in female infertility is still controversial. This study was conducted to evaluate the effect of acute and chronic schistosomiasis mansoni infection on the endometrium using immunohistochemical analysis of uterine hormone receptor expression. METHODS: Twenty-four nonpregnant swiss albino mice were divided into three groups: control, noninfected; acute; and chronic Schistosoma mansoni infection. Histological sections of uterine specimens were examined by light microscope with an image analyzing system to detect structural histological, estrogen receptor (ER) and progesterone receptor (PR) expression in the endometrium. RESULTS: No secretory phase was detected in the endometrium in acute and chronic Schistosoma infection. Hormone receptor expression (ER and PR) showed statistically significant differences among the groups (p< 0.05), with significant low ER hormone expression in chronic infection, compared to control proliferative, control secretory and acute infection cases, and statistically significant high PR expression in both acute and chronic infection cases compared to the control secretory cases (p< 0.05). CONCLUSIONS: Schistosomiasis mansoni seems to have an important impact on the hormone expression of affected women. Further studies to explore the mechanism of such changes are recommended.

【 授权许可】

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