Epigenetic markers in the embryonal germ cell development and spermatogenesis

Basic and Clinical Andrology

Review Article

Maciej Kurpisz¹  Marta Olszewska¹  Amadeusz Odroniec¹ 

[1] Institute of Human Genetics, Polish Academy of Sciences, Strzeszynska 32, 60–479, Poznan, Poland;

关键词: Sperm epigenetics;    DNA methylation;    Histone methylation;    Histone acetylation;    Spermatogenesis;    Fertilization;    Spermatozoa;    Epigénétique des Spermatozoïdes;    Méthylation de l’ADN;    Méthylation des Histones;    Acétylation des Histones;    Spermatogenèse;    Fécondation;    Spermatozoïdes;   

DOI  :  10.1186/s12610-022-00179-3

 received in 2022-07-31, accepted in 2022-11-25,  发布年份 2022

来源: Springer

【 摘 要 】

Spermatogenesis is the process of generation of male reproductive cells from spermatogonial stem cells in the seminiferous epithelium of the testis. During spermatogenesis, key spermatogenic events such as stem cell self-renewal and commitment to meiosis, meiotic recombination, meiotic sex chromosome inactivation, followed by cellular and chromatin remodeling of elongating spermatids occur, leading to sperm cell production. All the mentioned events are at least partially controlled by the epigenetic modifications of DNA and histones. Additionally, during embryonal development in primordial germ cells, global epigenetic reprogramming of DNA occurs. In this review, we summarized the most important epigenetic modifications in the particular stages of germ cell development, in DNA and histone proteins, starting from primordial germ cells, during embryonal development, and ending with histone-to-protamine transition during spermiogenesis.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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