Risk Factors of Stroke in Western and Asian Countries: A Systematic Review and Meta-analysis of Prospective Cohort Studies

BMC Public Health

Research Article

Xiao-Hua Andrew Zhou¹  Wen Rao²  Hui Lin³  Dali Yi⁴  Dong Yi⁴  Yanqi Zhang⁴  Liang Zhou⁴  Dihui Ma⁴  Ling Liu⁴  Xiaoyu Liu⁴  Yazhou Wu⁴  Xuetao Chen⁵  Dixiang Cheng⁶ 

[1] Department of Biostatistics, School of Public Health and Community Medicine, University of Washington, 98124-6108, Seattle, USA;Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, 400038, Chongqing, China;Department of Epidemiology, Institute of tropical medicine, Third Military Medical University, 400038, Chongqing, China;Department of Health Statistics, College of Preventive Medicine, Third Military Medical University, PO Box 400038, Chongqing, China;Department of Health Statistics, College of Preventive Medicine, Third Military Medical University, PO Box 400038, Chongqing, China;Department of Information, Xinqiao Hospital, Third Military Medical University, Xinqiao Street, 400037, Chongqing, China;School of Software Engineering, Chongqing University of Posts and Telecommunications, 400065, Chongqing, China;

关键词: Stroke;    Risk factors;    Prospective study;    Epidemiology;    Systematic review;    Public health;   

DOI  :  10.1186/1471-2458-14-776

 received in 2014-04-03, accepted in 2014-07-03,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThere has been an increasing trend in the incidence of stroke worldwide in recent years, and the number of studies focusing on the risk factors for stroke has also increased every year. To comprehensively evaluate the risk factors of stroke identified in prospective Western and Asian cohort studies.MethodsPopulation-based cohort studies on stroke were searched in databases (PubMed, EMBASE, Web of Science, Google Scholar, etc.), and the library of the Third Military Medical University was manually searched for relevant information. A meta-analysis of Western and Asian studies on risk factors was performed. The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to assess the final group of cohort studies.ResultsAfter screening, 22 prospective cohort studies were included in the analyses of this investigation. Two factors, smoking and alcohol consumption, showed statistically significant differences between Western and Asian populations, and the results were as follows (W/A): 2.05 (95% CI, 1.68 ~ 2.49)/1.27 (95% CI, 1.04 ~ 1.55) and 0.89 (95% CI, 0.76 ~ 1.04)/1.28 (95% CI, 1.07 ~ 1.53). The factor BMI = 18.5-21.9 kg/m2 showed statistically significant differences only in Western populations, 0.96 (95% CI, 0.93 ~ 0.99); the factor SBP = 120-139 mm Hg showed statistically significant differences only in Asian populations, 2.29 (95% CI, 1.04 ~ 5.09).ConclusionsThe prevalences of risk factors affect the stroke morbidity in Western and Asian populations, which may be biased by race. The meta-analysis of population-based studies suggests that different preventive measures should be adopted for Western and Asian population groups that are at high risk for stroke.

【 授权许可】

Unknown   
© Chen et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.