Oral symptoms and salivary findings in oral lichen planus, oral lichenoid lesions and stomatitis

BMC Oral Health

Research Article

Claus Zachariae¹  Jeanne Duus Johansen²  Kasper Rosing³  Anne Marie Lynge Pedersen⁴  Kristine Roen Larsen⁴  Jesper Reibel⁴ 

[1] Department of Dermatology and Allergy, Gentofte University Hospital, 28 Kildegaardsvej, DK-2900, Hellerup, Denmark;National Allergy Research Centre, Department of Dermatology and Allergy, Gentofte University Hospital, 28 Kildegaardsvej, DK-2900, Hellerup, Denmark;Section for Community Dentistry, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, 20 Noerre Allé, DK-2200, Copenhagen N, Denmark;Section for Oral Pathology and Oral Medicine, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, 20 Noerre Allé, DK-2200, Copenhagen N, Denmark;

关键词: Oral lichen planus;    Lichenoid lesions;    Xerostomia;    Salivary secretion;    Total protein;    sIgA;   

DOI  :  10.1186/s12903-017-0393-2

 received in 2017-02-10, accepted in 2017-06-16,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundTo examine if patients with oral lichen planus, oral lichenoid lesions and generalised stomatitis and concomitant contact allergy have more frequent and severe xerostomia, lower unstimulated and chewing-stimulated saliva and citric-acid-stimulated parotid saliva flow rates, and higher salivary concentration of total protein and sIgA than cases without contact allergy and healthy controls.MethodsForty-nine patients (42 women, aged 61.0 ± 10.3 years) and 29 healthy age- and gender-matched subjects underwent a standardised questionnaire on general and oral health, assessment of xerostomia, clinical examination, sialometry, mucosal biopsy and contact allergy testing.ResultsNineteen patients had oral lichen planus, 19 patients had oral lichenoid lesions and 11 patients had generalised stomatitis. 38.8% had contact allergy. Xerostomia was significantly more common and severe in patients (46.9%) than in healthy controls, whereas the saliva flow rates did not differ. The patients had higher sIgA levels in unstimulated and chewing-stimulated saliva than the healthy controls. The total protein concentration in saliva was lower in the unstimulated saliva samples whereas it was higher in the chewing stimulated saliva samples from patients when compared to healthy controls. The differences were not significant and they were irrespective of the presence of contact allergy.ConclusionXerostomia is prevalent in patients with oral lichen planus, lichenoid lesions and generalised stomatitis, but not associated with salivary gland hypofunction, numbers of systemic diseases or medications, contact allergy, age, or gender. Salivary sIgA levels were higher in patients than in healthy controls, but did not differ between patient groups. The total salivary protein concentration was lower in unstimulated saliva samples and higher in chewing-stimulated saliva samples in patients than in healthy controls, but did not differ between patient groups. Our findings do not aid in the discrimination between OLP and OLL and these conditions with or without contact allergic reactions.

【 授权许可】

CC BY   
© The Author(s). 2017