Acthaside: a new chromone derivative from Acacia ataxacantha and its biological activities

BMC Complementary and Alternative Medicine

Research Article

Mélanie Bourjot¹  Catherine Vonthron-Sénécheau¹  Ambaliou Sanni²  Abdou Madjid O. Amoussa²  Latifou Lagnika² 

[1] Laboratoire d’Innovation Thérapeutique, Faculté de Pharmacie, UMR CNRS-Unistra 7200, 74 route du Rhin, CS 60024, 67401, Illkich, France;Unité de Biochimie et Biologie Moléculaire, Equipe de Biochimie et Substances Naturelles Bioactives, Faculté des Sciences et Techniques, Université d’Abomey-Calavi, 04 BP 0320, Cotonou, Benin;

关键词: Acacia ataxacantha;    acthaside;    Antimicrobial;    Antioxidant;   

DOI  :  10.1186/s12906-016-1489-y

 received in 2016-06-02, accepted in 2016-11-29,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundAcacia ataxacantha (Fabaceae), used in traditional medicine grows in the South-West of Bénin. Ethyl acetate extract of the barks of this species was previously reported to display various bioactivities, including antibacterial, antifungal and antioxidant activities. In the present study, we investigate the antimicrobial and antioxidant activities of compound isolated from ethyl acetate extract of Acacia ataxacantha.MethodsPurification, isolation and structural identification of isolated compound were done using various chromatographic and spectroscopic methods. Antimicrobial activity was investigated using a two-fold serial microdilution method. The inhibitory potency of isolated compound was evaluated by kinetic experiments. The antioxidant activity was also determined using 2, 2-diphenyl-1-picrylhydrazyl.ResultsThe isolated compound was identified as 7-hydroxy-2-methyl-6-[β-galactopyranosyl-propyl]-4H-chromen-4-one. As far as we know, this compound, named “acthaside”, reported for the first time, was active against all tested microorganisms with minimal inhibitory concentration ranging from 25 to 50 μg/ml. At 50 μl/ml, no growth was observed in almost all tested microbial after 24 h of exposure. The isolated compound had significant antioxidant activity with an IC50 value of 3.61 ± 0.12 μg/ml compared to quercetin (IC50 1.04 ± 0.01 μg/ml).ConclusionThe present work demonstrates that the new chromen derivative isolated from A. ataxacantha may help treat bacterial and yeast infections. However, further studies are required to clarify the mechanism of action of this compound.

【 授权许可】

CC BY   
© The Author(s). 2016