Circulating Angiopoietins-1 and -2, Angiopoietin Receptor Tie-2 and Vascular Endothelial Growth Factor-A as Biomarkers of Acute Myocardial Infarction: a Prospective Nested Case-Control Study

BMC Cardiovascular Disorders

Research Article

Bruce H Phelps¹  Edward R McCluskey¹  Evangelos Hytopoulos¹  Charles P Quesenberry²  Carlos Iribarren²  Jeanne A Darbinian²  Joseph H Vogelman³  Norman Orentreich³ 

[1] Aviir, Inc, 2463 Faber Place, 94303, Palo Alto, CA, USA;Kaiser Permanente Division of Research, 2000 Broadway, 94612, Oakland, CA, USA;Orentreich Foundation for the Advancement of Science, Inc, 855 Route 301, 10516, Cold Spring-on-Hudson, NY, USA;

关键词: angiogenesis;    acute myocardial infarction;    epidemiology;   

DOI  :  10.1186/1471-2261-11-31

 received in 2010-08-18, accepted in 2011-06-14,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundAngiogenesis is up-regulated in myocardial ischemia. However, limited data exist assessing the value of circulating angiogenic biomarkers in predicting future incidence of acute myocardial infarction (AMI). Our aim was to examine the association between circulating levels of markers of angiogenesis with risk of incident acute myocardial infarction (AMI) in men and women.MethodsWe performed a case-control study (nested within a large cohort of persons receiving care within Kaiser Permanente of Northern California) including 695 AMI cases and 690 controls individually matched on age, gender and race/ethnicity.ResultsMedian [inter-quartile range] serum concentrations of vascular endothelial growth factor-A (VEGF-A; 260 [252] vs. 235 [224] pg/mL; p = 0.01) and angiopoietin-2 (Ang-2; 1.18 [0.66] vs. 1.05 [0.58] ng/mL; p < 0.0001) were significantly higher in AMI cases than in controls. By contrast, endothelium-specific receptor tyrosine kinase (Tie-2; 14.2 [3.7] vs. 14.0 [3.1] ng/mL; p = 0.07) and angiopoietin-1 levels (Ang-1; 33.1 [13.6] vs. 32.5 [12.7] ng/mL; p = 0.52) did not differ significantly by case-control status. After adjustment for educational attainment, hypertension, diabetes, smoking, alcohol consumption, body mass index, LDL-C, HDL-C, triglycerides and C-reactive protein, each increment of 1 unit of Ang-2 as a Z score was associated with 1.17-fold (95 percent confidence interval, 1.02 to 1.35) increased odds of AMI, and the upper quartile of Ang-2, relative to the lowest quartile, was associated with 1.63-fold (95 percent confidence interval, 1.09 to 2.45) increased odds of AMI.ConclusionsOur data support a role of Ang-2 as a biomarker of incident AMI independent of traditional risk factors.

【 授权许可】

CC BY   
© Iribarren et al; licensee BioMed Central Ltd. 2011